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5 Written questions

5 Matching questions

  1. DNA technology has many medical applications. Which of the following isnot done routinely at present?
    A) production of hormones for treating diabetes and dwarfism
    B) production of microbes that can metabolize toxins
    C) introduction of genetically engineered genes into human gametes
    D) genetic testing for carriers of harmful alleles
    E) prenatal identification of genetic disease alleles
  2. Which of the following is one of the technical reasons why gene therapy is problematic?
    A) Most cells with an engineered gene do not produce gene product.
    B) Transferred genes may not have appropriately controlled activity.
    C) Most cells with engineered genes overwhelm other cells in a tissue.
    D) mRNA from transferred genes cannot be translated.
    E) Cells with transferred genes are unlikely to replicate
  3. Expression of a cloned eukaryotic gene in a bacterial cell involves many challenges. The use of mRNA and reverse transcriptase is part of a strategy to solve the problem of
    A) post-translational processing.
    B) restriction fragment ligation.
    C) nucleic acid hybridization.
    D) post-transcriptional processing.
    E) electroporation.
  4. Some viruses can be crystallized and their structures analyzed. One such virus isDesmodium, or yellow mottle virus, which infects beans. This is a member of the tymovirus group and has a single-stranded RNA genome of ~6,300 nucleotides. Its virion is 25—30 nm in diameter, and is made up of 180 copies of a single capsid protein that self-associate to form each capsomere, which has icosahedral symmetry with 20 facets.
    If this virus has capsomeres with 20 facets, how many proteins form each one?
    A) 1
    B) ~6
    C) 5
    D) ~180
    E) ~20
  5. One hereditary disease in humans, called xeroderma pigmentosum (XP), makes homozygous individuals exceptionally susceptible to UV-induced mutation damage in the cells of exposed tissue, especially skin. Without extraordinary avoidance of sunlight exposure, patients soon succumb to numerous skin cancers. Which of the following best describes this phenomenon? A) inherited predisposition to mutation
    B) susceptibility to chemical carcinogens
    C) inherited inability to repair UV-induced mutation
    D) embryonic or fetal cancer
    E) inherited cancer taking a few years to be expressed
  1. a D) post-transcriptional processing
  2. b B) ~6
  3. c B) Transferred genes may not have appropriately controlled activity
  4. d C) introduction of genetically engineered genes into human gametes
  5. e C) inherited inability to repair UV-induced mutation

5 Multiple choice questions

  1. B) RNA polymerase must bind to the promoter, and the repressor must be inactive
  2. D) A retrovirus is used to introduce four specific regulatory genes
  3. A) Eukaryotic exons may be spliced in alternative patterns
  4. A) the ampicillin broth and the nutrient broth
  5. C) The engineered cells, when reintroduced into the patient, find their way back to the bone marrow

5 True/False questions

  1. RNAi methodology uses double-stranded pieces of RNA to trigger a breakdown or blocking of mRNA. For which of the following might it more possibly be useful?
    A) to decrease the production from a harmful gain-of-function mutated gene
    B) to raise the rate of production of a needed digestive enzyme
    C) to raise the concentration of a desired protein
    D) to destroy an unwanted allele in a homozygous individual
    E) to form a knockout organism that will not pass the deleted sequence to its progeny
    D) Dicer enzyme has reduced it to smaller double-stranded pieces


  2. As genetic technology makes testing for a wide variety of genotypes possible, which of the following is likely to be an increasingly troublesome issue?
    A) discrimination against certain racial groups because of major genetic differences
    B) the need to legislate for the protection of the privacy of genetic information
    C) using technology to identify genes that cause criminal behaviors D) alteration of human phenotypes to prevent early disease
    E) use of genotype information to provide positive identification of criminals
    B) the need to legislate for the protection of the privacy of genetic information


  3. Viral envelopes can best be analyzed with which of the following techniques?
    A) transmission electron microscopy
    B) staining and visualization with the light microscope
    C) immunofluorescent tagging of capsid proteins
    D) antibodies against specific proteins not found in the host membranes
    E) use of plaque assays for quantitative measurement of viral titer
    A) fusion of an adult cell's nucleus with an enucleated sheep egg, followed by incubation in a surrogate


  4. To cause a human pandemic, the H5N1 avian flu virus would have to
    A) become much more pathogenic.
    B) spread to primates such as chimpanzees.
    C) arise independently in chickens in North and South America.
    D) become capable of human-to-human transmission.
    E) develop into a virus with a different host range.
    E) bind to the repressor protein and activate it


  5. A geneticist introduces a transgene into yeast cells and isolates five independent cell lines in which the transgene has integrated into the yeast genome. In four of the lines, the transgene is expressed strongly, but in the fifth there is no expression at all. Of the lines that express the transgene, one is transcribed but not translated. Which of the following is a likely explanation?
    A) high histone acetylation
    B) no compatible ribosome
    C) missing transcription factor
    D) no AUG in any frame
    E) no promoter
    D) Dicer enzyme has reduced it to smaller double-stranded pieces


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