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5 Written Questions

5 Matching Questions

  1. Number of known survivors from rabies
  2. Symptoms of hemorrhagic fevers caused by lassa, Ebola
  3. Viruses with mosquito vectors
  4. Vaccines available
  5. Hemorrhagic fevers
  1. a Yellow fever → for humans, live/attenuated virus
    WEE, EEE, VEE → for horses, not humans
  2. b WEE
    La Crosse encephalitis
    dengue fever
    West Nile virus
  3. c Severe hemorrhage due to viral cytopathic effect in the vascular endothelium
  4. d High fever and bleeding are the primary symptoms
    -mortality rates can be as high as 80%
    -bleeding is due to multiple mechanisms depending on the virus
  5. e 1

5 Multiple Choice Questions

  1. Mosquito bites its subject injecting a bit of saliva containing the virus into the blood bypassing the skin barrier
  2. Virus is shed into the feces of the tick and onto the skin of the human; itching introduces the contaminated feces into the host by breaking the skin barrier
  3. Liver disrupts production of clotting factors leading to bleeding
    -black vomit can also be seen
  4. -lassa virus -arena virus (Small rodents)
    -marburg virus - filovirus (Rodents/monkeys)
    - Ebola - filovirus (rodents/monkey)
    * all of these cause hemorrhagic fever
  5. -Arthropod borne
    -can be transmitted by bloodsucking arthropods including tics, sand flies, and mosquitoes

5 True/False Questions

  1. Negri bodiesEosinophilic cytoplasmic inclusion body found in nerves and characteristic of rabies


  2. Hantavirus pulmonary syndromeCaused by the sin nombre virus
    -mechanism of infection is inhalation of dried rodent urine and feces
    -target organ = lungs → pulmonary edema
    -little inflammation, necrosis, or cytopathic effect
    -mortality rate is 76%


  3. diagnosis of insect vector diseases1. Cultures are available for most of the Arboviruses
    -not routine
    -may involve inoculation of newborn mice
    2. diagnosis is usually made by serology using acute and convalescent sera
    -obtaining a sample can be troublesome
    -blood only contains virus during viremia
    -stool is negative
    -viruses rarely found in the throat or CNS
    3. PCR looks promising


  4. Rabies-Arthropod borne
    -can be transmitted by bloodsucking arthropods including tics, sand flies, and mosquitoes


  5. Complexities of arboviruses-Introduced into the bloodstream by infected insects
    -viral replication in reticuloendothelial system in vascular epithelium
    -secondary viremia can seed target organs


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