Hemostasis and coagulation- calvarez2

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Term 1, Unified Exam 2, Margaret Anderson

_____ is the process that stops bleeding from a damaged blood vessel

hemostasis

Hemostasis is the process that _____

stops bleeding from a damaged vessel

Excessive bleeding and blood loss is called _____

hemorrhage

Hemorrhage is the opposite of _____

hemostasis

When a vessel is injured, processes are set in motion to _____

form a clot

Clot formation is called _____

coagulation

_____ is called coagulation

clot formation

A clot that is so large that it occludes a vessel is called a _____

thrombus

Thrombus is _____

a clot that occludes a vessel

A clot that is so unstable that it can be dislodged and occlude a vessel downstream is called _____

embolus

embolus

A clot that is so unstable that it is dislodged and occludes a vessel downstream

Clot formation must be accomplished WHILE _____

letting blood to continue to flow through the injured vessel during repair

When the wound to a vessel is repaired, a clot must be _____

dissolved

T or F:
Clotting and hemostasiscan maintain the integrity of a severed major artery

False:
A tourniquet must be applied to prevent excessive bleeding

Functions of plasma proteins

Contribute to colloid osmotic (oncotic) pressure, defend against foreign invaders, participate in blood clotting, are carriers for hormones and cholesterol and ions, serve as signaling molecules and extracellular enzymes or cytokines

Function of Albumins

Major contributors to oncotic pressure of plasma; carriers of various substances

Organ source of Albumins

Liver

Function of globulins

clotting factors, enzymes, antibodies, carriers for various substances

organ source of globulins

liver and lymphoid tissues

function of fibrinogen

forms fibrin threads essential to blood clotting

organ source of fibrinogen

liver

function of transferrin

iron transport

organ source of transferrin

liver and other tissues

hematopoiesis

synthesis of blood cells

When does hematopoiesis begin?

Hematopoiesis begins at about the 3rd week of embryonic development and continues throughout life

3 main types of blood cells:

Red blood cells, white blood cells, platelets

platelets AKA _____

thrombocytes

**In primary hemostasis, formation of the platelet plug requires

collagen because collagen gets exposed and then everything else gets activated

**What other molecules besides collagen are involved in primary hemostasis

Integrins, platelet aggregating factors

**Timing

...

mengiococcemia, niceria bacteria

...

treatment for meningicoccemia

protein C

Chemical Factors involved in coagulation

...

**plasminogen is incorporated into the clot, not _____

plasmin

tPA is released by the _____

damaged endothelium

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