Path - Chp 28 - 04
Order by
14 terms
Terms | Definitions |
|---|---|
 Spinocerebellar ataxia: | cerebellum, brainstem, spinal cord, peripheral n (neuronal loss) |
| Friedreich ataxia: | spinocerebellar degen begins 1st 10 yrs (gait ataxia) -> hand clumsiness, dysartharia, ↓reflex (autosomal recessive) |
| Friedreich ataxia (molecular): | expansion of GAA repeat |
| Friedreich ataxia (morph): | spinal cord - loss of axons, heart - enlarged, pericardial adhesions |
| ataxia-teleangiectasia: | axatic-dyskinetic (early childhood) |
| ataxia-teleangiectasia (molecular): | ATM (mutated gene) -> ↑x-ray induced abn, replicate damaged DNA |
| ataxia-teleangiectasia (morph): | cerebellum - loss of Purkinje/granule cells, lesions in conjunctiva, skin (face,neck,arms) |
| Amyotrophic Lateral Sclerosis (ALS): | lower motor - spinal cord /brainstem upper motor - corticospinal tract |
| ALS (molecular): | SOD1 (chr 21) mutation |
| ALS (morph): | ↓anterior-horn neurons (gliosis), Bunina bodies |
| Bunina bodies: | remnants of autophagic vacuoles |
| ALS (clinical): | fasciculations, progressive muscular atrophy or bulbar palsy |
| bulbospinal atrophy (kennedy syndrome): | x-linked, distal limb amyotrophy, bulbar signs (tongue, aphasia) ↑CAG repeats, androgen receptor |
| spinal muscular atrophy: | LMN in children |
First Time Here?
Welcome to Quizlet, a fun, free place to study. Try these flashcards, find others to study, or make your own.