Path - Chp 28 - Tumor 01
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32 terms
Terms | Definitions |
|---|---|
 tumors, gliomas (example) | astrocytoma, oligodendroglioma, ependymoma |
| tumors, major classes | glioma, neuronal tumor, poorly differentiated |
| brain tumors - children, (location) | posterior fossa |
| brain tumors - adults (location): | above the tentorium |
| tumors, most common grp | glioma |
| astrocytoma (classes) | infiltrating, non-infiltrating |
| astrocytoma (most common) | pilocytic % |
| infiltrating astrocytoma (occurrence) | 80% of adult primary brain tumor |
| infiltrating astrocytoma (grading) | histologic differentiation |
| infiltrating astrocytoma (grade II) | diffuse |
| infiltrating astrocytoma (grade III) | anaplastic |
| infiltrating astrocytoma (grade IV) | gliobastoma |
| infiltrating astrocytoma (location) | cerebellar hemispheres + others |
| infiltrating astrocytoma (age) | 4-6 decades |
| diffuse astrocytoma (morph) | poorly-defined gray-white, ↑cellularity, variable pleomorphism, indistinct border |
| anaplastic astrocytoma (morph) | ↑nuclear pleomorphism, mitotic bodies, eosinophilic bodies |
| glioblastoma (morph) | necrosis, vasc/endothel cell prolif, pseudopalisading, glomeruloid body |
| pseudopalisading | tumor cells, edge of necrotic region |
| primary glioblastoma | new onset, older pts (EGFR) |
| secondary glioblastoma | past hx of low grade %, young pts (p53) |
| diffuse astrocytoma (clinical) | 5+ year |
| glioblastoma (clinical) | leaky vessels, poor prognosis |
| pilocytic astrocytoma | grade I/IV, benign behavior |
| pilocytic astrocytoma (location) | cerebellum, ventricles, optic n |
| pilocytic astrocytoma (age): | children, young adult |
| pilocytic astrocytoma (morph) | often cystic, hairlike bipolar, rosenthal fibers, narrow infiltrative border |
| pleomorphic xanthoastrocytoma | temporal lobe (children/young adult), history of seizures |
| brainstem glioma | up to 20 y/o, pontine (worst), corticomedullary (intermediate), tectal (benign) |
| pleomorphic xanthoastrocytoma (location) | temporal lobe |
| pleomorphic xanthoastrocytoma (age) | children, young adult |
| pleomorphic xanthoastrocytoma (morph) | lipidized astrocytes |
| infiltrating astrocytoma (grade I) | pilocystic astrocytoma |
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