5 Written Questions

1. Blocks peptidoglycan synthesis
2. The ONLY drugs board tested where the metabolite of a drug is MORE lipid soluble than the parent compound...Leads to crystals in the urine and can cause tubulointerstitial nephritis
3. Third gen ceph
4. The more lipid soluble the anesthetic, the lower the MAC and the Greater the Potency
   MAC values are additive
   MAC values are lower in the elderly and in the present of sedative hypnotics
5. Nephrotoxicity and can cause ATN and hypocalcemia

5 Matching Questions

1. Side effects of Amantadine?
2. DOC for atypical bacteria?
3. What is Thiopental used for?
4. Most USMLE relevant use of TMP-SMX?
5. What are the side effects of Aminoglycosides??

1. a It is a barbituate used for induction...It is highly lipid soluble and has a rapid onset plus is short acting due to rapid redistribution.
2. b Atropine like due to its antimuscarinic nature but also
   LIVEDO RETICULARIS!**
3. c Prophylaxis against PCP pneumonia when CD4 count is below 200
4. d Macrolides... good treatment for
   Mycoplasma
   Chlamydia
   Ureaplasma
5. e Nephrotoxicity, esp if used in conjunction with a cephalosporin
   Ototoxicity, esp if used in conjunction with loop diuretics
   NEUROMUSCULAR BLOCKADE!! Acts like Botulinism in preventing release of ACh from presynaptic terminals

5 Multiple Choice Questions

1. Fluoroquinolones
   and
   Rifampin
   1. What are two antibacterial drugs that inhibit nucleic acid synthesis?
   2. What are two general rules about the MAC value for Inhaled Anesthetics?
   3. What are the teratogenic effects of Carbamazepine?
   4. What is the MAC value WRT inhaled anesthetics?
2. It is an opiate drug, used to suppress cough
   1. What type of drug is Fluphenazine?
   2. What type of drug is Clomipramine and what is its typical BOARD tested use?
   3. What type of drug is Bromocryptine?
   4. What type of drug is Dextromethorphan and what is it used for?
3. The prototypical Typical Antipsychotic... Moderate EPS likelyhood, Has antimuscarinic properties and Strong and Alpha blocking properties.
   Can cause Corneal Deposits
   1. What type of drug is Bromocryptine?
   2. What type of drug is Chlorpromazine?
   3. What type of drug is Quetiapine?
   4. What type of drug is Nortriptyline?
4. TMP-SMX
   1. DOC for Nocardia infection?
   2. MOA of trimethoprim?
   3. What is Nystatin used for?
   4. MOA of Amphotericin B?
5. Blocks Na+ channels and Glutamate receptors
   1. What is the MOA of Lamotrigine?
   2. What is the MOA of Isoniazid?
   3. What is the use of Lamotrigine?
   4. What is the MOA of Phenytoin?

5 True/False Questions

1. Alternative drugs to use if allergy to cephs or penicillins? → Hemolytic anemia

   True        False

2. What is the MOA of Valproic Acid? → Blocks axonal Na+ channels in their inactive state, with the M-gate open and the H-gate closed so it prolongs the time before returning to an active conformation...Prevents seizure propogation, not the start of the seizure itself.

   True        False

3. Ketoconazole absorption is decreased by.. → Ceftriaxone

   True        False

4. What is the drug Buspirone used for clinically? → GAD

   True        False

5. What is extremely notable about Cefuroxine? → It is a second gen cephalosporin, the first antibiotic to cross the BBB because of its lipid solubility.

   True        False