| Term | Definition |
|---|
| excitatory postsynaptic potential | EPSP stands for... |
| inhibitory postsynaptic potential | IPSP stands for... |
| Na+ | What ion enters into cell during excitation? |
| Cl- | What ion enters into the cell during inhibition? |
| extensor paralysis | What happens if reciprocal inhibition between motor neurones in the spinal cord is blocked? |
| glutamate | The major excitatory neurotransmitter in the brain |
| GABA | The major inhibitory neurotransmitter in the brain |
| 50% | What percentage of neurons release glutamate as an excitatory neurotransmitter? |
| 30-40% | What percentage of neurons release GABA as an inhibitory neurotransmitter? |
| NMDA, AMPA, kainate | Name the 3 ionotropic glutamate receptors |
| mGLUR1-7 | Name a metabotropic glutamate receptor |
| A, C | Name the 2 ionotropic GABA subclasses of receptor |
| B1, B2 | Name the 2 metabotropic GABA subclasses of receptor |
| reduces excitation, increases inhibition | What does ethanol do in the brain? |
| enhances activation | What does ethanol do to some GABA-A receptors? |
| blocks | What does ethanol do to some NMDA receptors? |
| gamma-2L subunit | What criteria causes ethanol to act on a GABA-A receptor at 20mM doses? |
| delta subunit | What criteria causes ethanol to act on a GABA-A receptor at 5mM doses? |
| 0, 0.02, 0.05 | What are the 3 NSW blood alcohol limits? |
| blood alcohol concentration | What does BAC stand for? |
| GABA-A receptors | Many sedative drugs act on... |
| occupancy | If a drug causes a channel to be open for a longer time, it has a ___ mechanism |
| rate | If a drug causes a channel to open and close more frequently, it has a ___ mechanism |
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