Dr Gordon Crossword Chapter 13
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49 terms
Terms | Definitions |
|---|---|
 Lysosome | Organelle involved in intracellular digestion |
| trans Golgi network | The Golgi exit site |
| vacuole | The animal cell equivalent of the lysosome in plant and fungal cells |
| ARF | CopI and clathrin specific coat recruitment GTPase |
| Adaptor proteins | Links the coat protein indirectly to the transport vesicle membrane via transmembrane receptors |
| Autophagy | "Self eating"; intracellular pathway used to remove obsolete/damaged organelles |
| Cisternae maturation model | A model for Golgi structure and function that postulates that the cisternae are dynamic and mature to form later cisternae compartments (3 Words) |
| Clathrin | One type of coat protein; found on transport vesicles formed at the plasma membrane |
| ATP hydrolysis | Causes vesicle coat disassembly |
| Secretory granules | Specialized vesicles that contain highly concentrated and aggregated material destined for fusion with the plasma membrane (2 Words) |
| SAR1 | CopII specific coat recruitment GTPase |
| Exocytosis | Movement of protein and lipids outward; ER to cell surface transport |
| NSF | Catalyzes the disassembly of SNARE complexes in an ATP dependent manner |
| Heterotypic | Membrane fusion between two different compartments |
| EGF receptor | Example receptor which after endocytosis is delivered to the lysosome for degradation (2 Words) |
| Coated vesicles | Specialized transport vesicles covered with a cage of protein (2 Words) |
| Vesicular Tubular Cluster | Short lived compartment; delivers material from the ER to the Golgi (3 Words) |
| Pinocytosis | "Cellular drinking" |
| Calcium | An intracellular signal that triggers secretory vesicle fusion in neurons |
| Caveolin | Integral membrane protein involved in the formation of 'coat' independent pinocytic vesicles |
| Polarized | Refers to a cell that has two structurally and functionally distinct plasma membrane domains (e.g. neurons) |
| Regulated | Secretory pathway found in specialized cell types; used for the controlled secretion of hormones |
| Constitutive | Secretory pathway found in all cell types; always active |
| V-SNAREs | Found on transport vesicles; have a role in ensuring specificity of transport vesicle fusion |
| Phagocytosis | "Cellular eating" |
| ESCRT | Cytosolic protein complex involved in the formation of internal membrane vesicles found within multivesicular bodies |
| Retrieval pathway | Pathway used to return ER resident proteins that have escaped to the Golgi |
| Transcytosis | Endocytosis pathway used by gut epithelial cells to move maternal antibodies from one side of the cell to a different side |
| Transferrin | Soluble protein that carries iron; binds iron at neutral pH, releases iron at acidic pH |
| Acid hydrolases | All lysosomal enzymes fall into this category of proteins (2 Words) |
| Vesicular transport model | A model for Golgi structure and function that postulates that the cisternae are static and material moves through the Golgi via the formation of transport vesicles (3 Words) |
| Receptor mediated endocytosis | Endocytic pathway used to bring in specific extracellular material via receptor binding (3 Words) |
| Mannose 6 phosphate | Molecular tag added to lysosomal proteins in the Golgi to ensure proper targeting (3 Words) |
| Synaptic vesicles | Specialized secretory vesicles that form in nerve cells by the process of endocytosis (2 Words) |
| Neutrophils | Cell type that ingests invading microorganisms by phagocytosis as a means of defense against infection |
| Proton pumps | Responsible for the acidic environment of the lysosome (2 Words) |
| Dynamin | GTPase that functions to 'pinch' clathrin-coated vesicles from the membrane |
| Membrane bound | Characteristic of all Golgi resident proteins (2 Words) |
| Multivesicular bodies | Formed by invagination of early endosomes; internalized vesicles contain monoubiquitinated membrane proteins (2 Words) |
| Early endosome | Function as the "sorting station" for the endocytosis pathway (2 Words) |
| I-cell disease | Inherited disorder characterized by a defect in N-acetylglucosamine phosphotransferase activity (3 Words) |
| T-SNAREs | Found on target membranes; have a role in ensuring specificity of transport vesicle fusion |
| Rab proteins | GTPases that have a role in transport vesicle specificity (2 Words) |
| cis Golgi network | The entry point of the Golgi apparatus (abbr.) |
| Endocytosis | Movement of proteins and lipids inward; cell surface to lysosome transport |
| pH | The M6P receptor binds to M6P modified proteins in the TGN but releases its cargo in late endosomes due to changes in this |
| Assembled | One of two requirements that must be met for proteins to exit the ER |
| Cisternae | Golgi stacks |
| LDL | Cholesterol-protein complex whose cellular uptake is via receptor mediated endocytosis |
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