Exam 3 Cell Death
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8 terms
Terms | Definitions |
|---|---|
 factors to consider when determining an agents effectiveness | # of microbes, nature of microbes in population, Temp, pH of environment, MOA of the agent, concentration or dosage of agent, presence of solvents, organic matter, inhibitors |
| characteristics of good antimicrobial agents | Active Cells - more susceptible Closed Systems - 4 to 5 systems of growth (lag, log, SP, death) |
| Modes of Action | Cell wall, cell membrane, Protein and nucleic acid synthesis, protein function |
| Cell Wall - cellular target | blocks synthesis, digest/breakdown, cells lysis |
| Cell Membrane - cellular target | chemical inserts as surfactants. Drawback - concentration levels too high can effect membrane |
| surfactants | Highly effective - dissolve membrane Not effective - against envelope viruses and gram neg. |
| Protein and Nucleic Acid Synthesis - cellular target | wipe out function w/o side effects Target prokaryotes |
| Protein function | denature proteins (heat, pH, strong organic solvents, heavy metals) Block active site |
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