| Term | Definition |
| niche | a specific area |
| noisome | offensive |
| nonchalance | state of being nonchalant |
| nonchalant | casual |
| noncommittal | vague |
| nondescript | ordinary |
| nonentity | nobody |
| nook | a small sheltered place |
| nostalgic | homesick |
| notable | outstanding |
| notion | opinion |
| notoriety | infamy |
| novice | beginner |
| noxious | deadly |
| nuance | nicety |
| nubile | marriageable |
| nuisance | annoyance |
| nullify | cancel |
| obdurate | a person who refuses to change his mind |
| obfuscate | obscure |
| obligated | thankful |
| obligatory | necessary |
| oblige | gratify |
| oblivion | the state of being completely forgotten |
| oblivious | unaware |
| obscure | vague |
| obsequious | servile |
| obsolete | outdated |
| obstinate | stubborn |
| obstreperous | noisy and difficult to control |
| obstrusive | noticeable in an unpleasant way |
| obtuse | dull |
| occlusion | sealing |
| officious | interfering |
| olfactory | concerning with the ability to smell |
| ominous | grim |
| omission | exclusion |
| omnipotent | possessing infinite power |
| omnipresent | seeming to be always present |
| omniscient | all-knowing |
| omnivore | an animal that is naturally able to eat both plants and meat |
| omnivorous | absorbing or consuming everything |
| onerous | burdensome |
| onset | beginning |
| opaque | obscure |
| opportune | suitable |
| optimal | best |
| optimism | positivity |
| optimistic | positive |
| opulence | wealth |
| opulent | wealthy |
| orator | skillful and effective speaker |
| origin | birth |
| orthodox | conventional |
| ossified | solidified |
| ostensible | surface |
| ostentation | flashiness |
| ostentatious | showy |