| Term | Definition |
| omnifarious | of all kinds |
| omnipotent | all-powerful |
| omniscient | all-knowing |
| omnivorous | eating any kind of food; absorbing everything |
| onerous | burdensome; heavy |
| onslaught | a furious attack |
| onus | a burden; a responsibility |
| opague | not transparent |
| opiate | narcotic; causing sleep or relief |
| opportunist | one who takes advantage of a situation |
| oppress | to rule harshly; tyrannize |
| opprobrious | shameful; disgraceful |
| opt | to choose |
| optimist | one who sees the good side of things |
| optimum | the best; most favorable |
| opulent | rich; luxurious |
| oracular | mysterious; predicting |
| oration | a speech delivered on a special occasion |
| orbit | a curved path; such as a planet takes around the sun |
| ordain | to order; to establish; to arrange |