What does a pheochromocytoma look like grossly?
Yellow with areas of hemorrhage/necrosis (seems similar to cortical ca)
What do the cells in a neuroblastoma look like? What are the 3 types of differentiation of a NB and what is the definition of them?
Small, hyperchromatic nuclei and scanty cytoplasm arranged in sheets; indistinct cell borders; can have HW rosettes; undifferentiated (no neuropil); poorly-diff (<5% ganglionic diff); differentiating (>5% ganglionic)
In addition to subtype of differentiation, which additional 2 parameters determine the favorable/unfavorable outcome in NBs?
Age and MKI
What does a ganglioNB look like and what is an important element of the stroma?
Well-defined foci of NB cells show various stages of NB maturation to ganglionic diff and neuromatous/Schwannian background of at LEAST 50%
What does a mature ganglioneuroma look like?
Clusters or single mature ganglion cells in neural stroma