| Term | Definition |
|---|
| Tetracyclines , Macrolides , and Lincosamides. | Broad-Spectrum Antibiotics |
| Tetracyclines | Are group of Anti-Infectives composed of Natural and Semi-Synthetic Compounds. |
| Tetracyclines Actions | Exert their Effect by Inhibiting bacterial Protein Synthesis |
| Uses of Tetracycline | These Antibiontics are Effective in the Treatment of Infections Caused by a Wide Range of Gram-Negative and Gram- Positive Microorganisms. These are Broad Spectrum Antibiotics. |
| Tetracycline use in illnesses | Intestinal Amebiasis, Typhus fever , and Tick Fevers some Skin and Soft tissue Infections, Uncomplicated Urethral , Enocervical or Rectal infections caused by Chlamydia Trachomatis , severe Acne as an adjunctive treatment, infections with Helocobacter Pylora |
| Adverse Reactions GI reactions | Nausea or Vomiting, Diarrhea , Epigastric Distress, Stomatitis , Sore Throat, Other; Skin Rashes , Photosensitivity Reaction, its seems to Cause the Most Serious Photo Sensitivity Reaction. |
| Tetracyclines Contraindications | The Tetracyclines are contraindicated in the patient known to be Hypersensitibe to any of the Tetracycline during Pregnancy because of the Possibility of Toxic Effects to the Baby (pregnancy category D ) and during lactation and in children younger than 9 years old |
| Nursing Alert (children) | Do not recomended in Children younger than 9 of age unless their use is a must because these drugs may cause permanent yellow- gray teeth also, prolonged or repeated therapy may result in over growth of non-susceptible bacterial or fungal organisms |
| Precautions Tetracycline | Should be use Cautiously in patients with Impaired Renal Function (if degradation Occurs the Agents Are Highly Toxic to the Kidneys) and those with Liver Impairment (Doses greater than 2 g/day Can be Extremely Damaging to the Liver). |
| Tetracyclines Interactions | Anticids containing Aluminum, Zinc, Magnesium, or Bismuth Salts; Common use relief of Heartburn GI upset = (decrease effectiveness of Tetracycline) Oral Anticoagulants (blood thinner )= Increaded risk for bleeding , Oral Contraceptives (birth control) Decreased Effectiveness of Contraceptive Agent ( break through bleeding or pregnancy, Digoxin( management of heart disease ) Increased Risk for Digitalis Toxicity |
| Chronic Alert (diabetics) | Tetracycline may reduce Insulin Requirements in Patients with Diabetes , Blood Glucose Levels should be Monitored Frequently During Tetracycline Therapy |
| Tetracyclines Interactions | Anticids containing Aluminum, Zinc, Magnesium, or Bismuth Salts |
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