COX-2 Inhibitors

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Pharm Exam 3

CYCLO-OXYGENASE TYPE 2 ENZYME

COX-2 is the acronym for _________________.

CYCLO-OXYGENASE TYPE 2 ENZYME

COX-2 inhibitors inhibit ______________.

CYCLO-OXYGENASE TYPE 2 ENZYME

_________________ is the enzyme responsible for producing prostaglandins which cause pain at sites of surgery, infection and inflammation.

PROSTAGLANDINS

Cyclo-oxygenase type 2 enzyme is the enzyme responsible for producing _______________ which cause pain at sites of surgery, infection and inflammation.

PAIN AT SITES OF SURGERY, INFECTION AND INFLAMMATION

Cyclo-oxygenase type 2 enzyme is the enzyme responsible for producing prostaglandins which cause ____________________.

PROSTAGLANDINS

When cyclo-oxygenase type two enzymes are inhibited, less __________ are produced and there is less pain.

CELOCOXIB (CELEBREX)

What is the one drug within the group of COX-2 inhibitors?

FALSE! These drugs were developed because they caused LESS incidence of gastric ulcers compared to NSAIDs (ibuprofen, naproxen)...so good for patients with arthritis taking the drug for a long time and not suffer from ulcers....its also used to diminish dental pain

T or F? COX-2 inhibitors are not used for long periods of time because they have a higher incidence of causing GI ulcers.

COX-1 = produces prostaglandins in the GI tract that act as a protective substance against the formation of ulcers
COX-2 = produces prostaglandins which cause pain at sites of surgery, infection and inflammation

What is the difference between COX-1 and COX-2 enzymes?

NSAIDs (ibuprofen and aspirin) inhibit COX-1 enzymes thus diminishing the formation of the protective GI prostaglandins

What happens when COX-1 enzymes are inhibited?

LESS PROSTAGLANDINS ARE PRODUCED AND THERE IS LESS PAIN

What happens when COX-2 enzymes are inhibited?

BOTH COX-1 AND COX-2 soooo.....they are effective in pain reduction but also have the capability to produce ulcers, where COX-2 inhibitors will inhibit pain with a much lower chance of causing ulcers.

What enzymes do traditional NSAIDs inhibit?

Stomatitis, abnormal taste, xerostomia (normal salivary flow resumes upon discontinuation), and tooth disorder.

What are the effects on dental treatment of Celecoxib (celebrex)?

Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase-2 (COX-2), which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties. Celecoxib does not inhibit cyclooxygenase-1 (COX-1) at therapeutic concentrations.

Describe the mechanism of action of celecoxib (celebrex).

TRUE! Have Antipyretic, analgesic and anti-inflammatory properties

T or F? COX-2 inhibitors reduce inflammation.

FALSE!

T or F? COX-2 inhibitors are used in medicine to treat seizures.

TRUE!

T or F? COX-2 inhibitors are used in medicine to treat rheumatoid arthritis

FALSE! NSAID, COX-2 SELECTIVE

T or F? COX-2 inhibitors are classified as a narcotic analgesic.

TRUE!

T or F? COX-2 inhibitors reduce both pain and swelling.

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