Developmental Bio Exam #3
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Created by:
JamiesonHaak on March 13, 2012
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22 terms
Terms | Definitions |
|---|---|
 Bicoid | anterior Binds and inhibits caudal Bicoid deficient mutant: Double tail Bicoid "rescue" expts: wherever inserted gives rise to "head" region |
| nanos | posterior Binds and inhibits hunchback nanos deficient mutant: no abdomen anchored by staufen and oskar |
| Torso | both anterior and posterior Torso is a RTK.... represses groucho tailless and huckbein mRNA in association with torso torso deficient mutant: no telson and acron |
| torso-like | ligand activates torso which represses Groucho |
| Groucho | middle inhibited by torso represses tailless and hucklebein |
| caudal | posterior inhibited by bicoid (binds to the 3' UTR of caudal) |
| hunchback | ubiqiotous mRNA deadenylation in posterior (so only expressed in anterior) |
| Gap genes | muntants missing large regions |
| pair rule genes | mutants missing every other segment |
| segment polarity genes | missing half of each segment |
| mutual rerpression | both inhibit eachother in synctium blastoderm establishes polarity which gives rise to segments because of the morphogen gradients made |
| unilateral repression | hunchback does not directly inhibit krupel but ultimatley does |
| major primary pair rule genes | primary eve, rnt, paired |
| major secondary pair rule genes | add, ft3, sloppy-paired |
| what controls fine tuning of each segments? | modularity of enhancer regions of each gene comboniations of enahncers determines which stripe its in |
| fushi tarazu mutant | mutations at borders of segments, these parts are called para segments |
| parasegments | posterior of each parasegment has no expression regulation at each parasegment regulates where fuhi tarazu is found |
| what pathway are Wg and En in? | Wg-> Wnt En-> Transcription factor |
| what type of regulation occurs between adjacent parasegment border cells with engrailed and wingless? | recipricol regulation |
| what establishes the parasegement? | wg and en |
| Hox genes | homeotic genes that give rise to structures in the order of the genes on the chromosome (5' to 3') as anterior-posterior dont know why can express legs as antennae |
| Homeotic genes | Function: activate and repress the "realisator" genes which form tissue and organ primordia repressed by polycomb activated by trithorax |
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