what type of infection is neutralization best for?
what are the best neutralizing antibodies?
IgA and IgG
What three antibodies are capable of neutralization?
IgA, IgG and IgM.
A and M can cross link and aggregate
what is digeorge syndrome? what are these children particularly susceptible to?
children born without a thymus, are fcked if they come into contact with an intracellular pathogen.
What are two cytokines secreted by CTLs?
IFN-gamma (activates macrophages to be extra pissed and have more oxidative burst to kill pathogens they have ingested)
TNF-Beta (enhances phagocytic activity of macrophages.)
What can be used to treat people with chronic granulomatous disease?
IFN-gamma. These patients cannot kill ingested pathogens, so if you give them IFN-gamma, they can do it!
General functions of cytokines secreted by CTLs
to activate macrophages.
IFN-gamma makes them better at bursting to kill intracellular pathogens
TNF-beta makes them more phagocytic.
What are the 4 cytokines secreted by Th1 cells?
What cytokines, when secreted by APCs, cause Th0s to differentiate into Th1s?
IFN-gamma and IL-12
What is the function of IL-2? Who makes it?
Th1s make IL-2, and activated T cells (here it promotes differentiation and proliferation). It also stimulates prolif of NK cells.
What cytokine, made by APCs and Th1s, inhibits Th2 differentiation?
What isotypes do Th1 cells stimulate B cells to switch to?
IgG1 and IgG3 - IFN-Gamma
IgA - TNF-Beta