humoral immunity
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Created by:
etwindo Plus on March 14, 2012
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12 terms
Terms | Definitions |
|---|---|
 what type of infection is neutralization best for? | viral |
| what are the best neutralizing antibodies? | IgA and IgG |
| What three antibodies are capable of neutralization? | IgA, IgG and IgM. A and M can cross link and aggregate |
| what is digeorge syndrome? what are these children particularly susceptible to? | children born without a thymus, are fcked if they come into contact with an intracellular pathogen. |
| What are two cytokines secreted by CTLs? | IFN-gamma (activates macrophages to be extra pissed and have more oxidative burst to kill pathogens they have ingested) TNF-Beta (enhances phagocytic activity of macrophages.) |
| What can be used to treat people with chronic granulomatous disease? | IFN-gamma. These patients cannot kill ingested pathogens, so if you give them IFN-gamma, they can do it! |
| General functions of cytokines secreted by CTLs | to activate macrophages. IFN-gamma makes them better at bursting to kill intracellular pathogens TNF-beta makes them more phagocytic. |
| What are the 4 cytokines secreted by Th1 cells? | IFN-gamma TNF-beta IL-2 IL-12 |
| What cytokines, when secreted by APCs, cause Th0s to differentiate into Th1s? | IFN-gamma and IL-12 |
| What is the function of IL-2? Who makes it? | Th1s make IL-2, and activated T cells (here it promotes differentiation and proliferation). It also stimulates prolif of NK cells. |
| What cytokine, made by APCs and Th1s, inhibits Th2 differentiation? | IL-12 |
| What isotypes do Th1 cells stimulate B cells to switch to? | IgG1 and IgG3 - IFN-Gamma IgA - TNF-Beta |
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