5 Written Questions

1. Cardiotoxicity; HF
   Flu-like symptoms;
   Hypesensitivity
2. Myelosuppression; nephrotoxic; ototoxic/tinnitus/hearing loss.
   Highly EMETOGENIC: 1 hour after dose, can last for days
   Peripheral neuropathy
3. Myelosuppression
   vesicant
4. Tumor lysis syndrome: characterized by acute renal failure, hyperkalemia,
   hypocalcemia, hyperuricemia, or hyperphosphatemia
5. Cardiotoxicity, HF, vesicant "flare"; reddish-orange urine
   alopecia
   1-2 days is not hematuria- it's med being excreted

5 Matching Questions

1. bevacizumab (Avastin)
2. Interleuken II
3. Docetaxel (Taxotere)
   Paclitaxel (Taxol)
4. Bleomycin (Blenoxane)
5. Epoetin (Epogen, Procrit)

1. a Hypertension; seizure activity; thrombosis
2. b GI perforation, impairs wound healing
3. c Hypersensitivity; leukopenia (low WBCs) can limit dose
   GI- N/V, diarrhea
   Bradycardia
   alopecia
4. d hypersensitivity (anaphylaxis)
   PNEUMONITIS, PULMONARY FIBROSIS
   MINIMAL bone marrow suppression
5. e Anaphylaxis, renal shutdown
   Severe hypotension; capillary leak syndrome, fluid shifts, widespread edema

5 Multiple Choice Questions

1. must be given to patients receiving methyltrexate (Folex) to save normal cells
   1. Zinecard
   2. Leucovorin
   3. Prednisone
   4. Mesnex
2. N/V; myelosupperssion; flu-like syndrome
   elevated serum transaminases; proteinuria; hematuria; rash
   1. Gemcitabine (Gemzar)
   2. Asparaginase (Elspar)
   3. Vinblastine (Velban)
   4. Cytarabine (Ara-C)
3. Bone marrow suppression, diarrhea (early, late)
   1. Bleomycin (Blenoxane)
   2. Irinotecan (Camptosar)
   3. Gemcitabine (Gemzar)
   4. Rituximab (Rituxan)
4. Nausea, HA, hot flashes, joint & musculoskeletal pain, osteoporosis
   1. Methotrexate (Folex)
   2. Bortezomib (Velcade)
   3. Anastrozole (Arimidex)
   4. Cytarabine (Ara-C)
5. Bone pain
   1. Vincristine (Oncovin)
   2. leuprolide (Lupron)
   3. Filgrastim (Neupogen)
   4. Vinblastine (Velban)

5 True/False Questions

1. Fluorouracil (5-FU) → Hot flushes, impotence, loss of libido, osteoporosis
   
   Alopecia, cardiac arrhythmias, breathing difficulties
   "chemical castration"

   True        False

2. leuprolide (Lupron) → must be given to patients receiving methyltrexate (Folex) to save normal cells

   True        False

3. Zinecard → protects against cardiac toxicity in pts taking Adriamycin

   True        False

4. Bortezomib (Velcade) → Bone marrow suppression, infusion rxs, infection

   True        False

5. Asparaginase (Elspar) → N/V, serum ammonia

   True        False