excretion-pharm midterm

16 terms by JsSaves101

Create a new folder

Advertisement Upgrade to remove ads

excretion

removal of drug from body

places drugs excreted from

kidney(urine)
liver (bile)
intestines (feces)
lungs
saliva/sweat/mamma glands

glomerlular filtration affected by:

1. kidney health/blood perfusion
2.chem/phys properties (only small mols filtered, protein bound drug is not filtered)
3. water soluble drugs can be reabsorbed in tubules
4. pH of urine

active secretion (affects kidney filtration)

proximal or distal tubules
active transport
penicillin concentrates in urine, good for UTI

liver secretion

bile stored in gallbladder, drugs actively secreted by livers cells into bile, through intestinal tract
-drug may get reabsorbed into body if its still lipophilic (enterohepatic circulation)

intestinal excretion

wormers, neomycin dont get absorbed orally, go out in feces

milk excretion

drugs go from blood to milk, may get ion trapped (normal pH of milk is 6-7, mastitis milk is 7-8)

half life of drug

amt of time it takes for half the drug to leave body
-antibiotics= 2-3 hr halflife
-barbituates= 30-70 hours

idiosyncrasy

abnormal response to drug by individual

hypersensitivity

decrease dose due to allergy/side effects

HOW DRUGS EXERT EFFECTS

-drug binds to target cells at receptor sites on cell
-receptor sites are different (unique for drug)
-drug + correct receptor= desired response

agonist

drug stimulates the site

antagonist

drug inhibits activity at site, blocks/reverses another drug's activity at the site

reversal agents

naloxone (opioids), flumazenil (valium), tolazoline (LA rompun)

synergism

sum of both drugs is greater than the benefit of each used and added up (2+2=5)

"potentiation"

quartermaster (pen G and dihydrostreptomycin) in dry cow's udder (2 drugs does better than each separately)

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set