Hypothalamus communication to Anterior Pituitary
Via hormones sent through portal vessel system.
Causes production of other hormones in Anterior Lobe
Produce Prolactin, which stimulates production of milk in mammary glands. Inhibited by dopamine
Proopiomelanocortin (POMC) causes production of ACTH, which ultimately results in production of cortisol in adrenal gland
Transcription factor necessary for transcription of ACTH and LH/FSH genes. Also essential for transcription of Pit1
Largest hormones known to date
TSH, FSH, LH, hCG(but placental, not pituitary)
Heterodimeric glycoproteins: all have same α subunit, but each has own β subunit
GH and PRL receptors
Both bind to Class 1 cytokine receptors: tyrosine kinase associated receptors.
Are very similar. GH can bind prolactin receptor, but not as strongly
Combined Pituitary Hormone Deficiency
mutations that can affect multiple hormones, many times in Prop-1 NOT sydromic