Endocrinology Lecture 2.1

18 terms by biotechie

Create a new folder

Advertisement Upgrade to remove ads

First half of second lecture. Anterior Pituitary Gland

5 anterior pituitary cell types

Somatotrophs
Lactotrophs
Corticotrophs
Gonadotrophs
Thyrotrophs

Hypothalamus communication to Anterior Pituitary

Via hormones sent through portal vessel system.
Causes production of other hormones in Anterior Lobe

Somatotrophs

Produce Growth Hormone, which stimulates production of IGF-1 in Liver and other organs

Lactotrophs

Produce Prolactin, which stimulates production of milk in mammary glands. Inhibited by dopamine

Corticotrophs

Proopiomelanocortin (POMC) causes production of ACTH, which ultimately results in production of cortisol in adrenal gland

Gonadotropes

Produce glycoproteins like FSH and LH that act on gonads

Thyrotropes

Produce TSH, which causes hormone production in Thyroid

Prop1

Transcription factor necessary for transcription of ACTH and LH/FSH genes. Also essential for transcription of Pit1

Pit1

Transcription factor for GH, PRL, and TSH
Transcriptionally regulated by Prop1

Three types of anterior pituitary hormones

Glycoproteins
Proopiomelanocortin
GH/PRL

Glycoproteins

Largest hormones known to date
TSH, FSH, LH, hCG(but placental, not pituitary)
Heterodimeric glycoproteins: all have same α subunit, but each has own β subunit

POMC

preoopiomelanocortin
Pre-prohormone that is cleaved into several hormones, including ACTH

GH and PRL receptors

Both bind to Class 1 cytokine receptors: tyrosine kinase associated receptors.
Are very similar. GH can bind prolactin receptor, but not as strongly

Pituitary Hormone Deficiency

Loss of hormone: Many or just one

Isolated Growth Hormone Deficiency

Mutation in GH gene or the receptor

Combined Pituitary Hormone Deficiency

mutations that can affect multiple hormones, many times in Prop-1 NOT sydromic

Syndromic Combined Pituitary Hormone Deficiency

Involves head development. Not prop-1 related

Pituitary Adenoma

Overproduction of hormone, usually just one hormone because the tumor arises from one cell

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set