BB3 Sex Variations

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Created by:

tb09k  on March 22, 2012

Subjects:

Psychology

Description:

Brain and Behavior Exam 3 Section 2

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BB3 Sex Variations

Difference in sexual behavior between males and females
-# of partners
-What is sought in a mate
-Psychology components: jealousy
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Difference in sexual behavior between males and females -# of partners
-What is sought in a mate
-Psychology components: jealousy
difference in sexual behavior within a given sex Sexual orientation: homosexual, heterosexual, bisexual
Difference between "Gender" and "Sex" Sex refers to XX and XY- what we're genetically born as
Gender refers to with whom we identify and what we call ourselves. Uniquely human
Difference between "Gender Identity" and "Sexual Orientation" Gender Identity: how we identify sexually and what we call ourselves
Sexual Orientation: what other sex we are physically attracted too
What does it mean to say sexual orientation/gender identity is continuos rather than categorical *Sexual orientation is more continuous for females and more categorical for males

*More men likely to say "I'm straight", not somewhere on the continuum, women more likely to place themselves on a continuum.
Evidence that genetics has a role in sexual orientation?*Homosexuality is strongly familial
-Similarity in Identical twins>fraternal twins
-Found for homosexual men and women
*Genes don't account for everything, influence from environment as well

*Epigenetic: experience adds chemical group to certain gene-->gene is inactivated-->parent passes inactivated gene-->heritable homosexuality without relying on the spread of a gene

*Homosexual individuals still pass on their genes
Evidence that Hormones have role in sexual orientation Adult hormone levels DO NOT differ
Evidence that Prenatal Hormones have roles in sexual orientation *Might have an effect
*Animal studies sort of suggest it- effects of castration on male rat pups or tesosterone on female rat pups
*Slight and partial feminizations in gay men and masculinizations in lesbians begin before puberty
-Bone Length
Evidence that Prenatal Stress has role in Sexual Orientation*Stress increases Endorphins which antagonize effects of Testosterone on hypothalamus
*Stress increases corticosterone which decreases Testosterone release

*In animal models of maternal stress (confinement and alcohol exposure)
-Maternal Confinement: as adults, male offspring more likely than offspring of non-stressed moms to lordorse in the presence of another male. Still engaged in typical male sexual behavior as well
-Maternal Confinement and Alcohol: more lordosis and less male typical sexual behavior

*In humans: 2 out of 3 studies moms of gay men reported more stress during pregnancy than moms of straight men
Differences in Brain Anatomy between Homosexual and Heterosexual indivuals Hemisphere size
Amygdala
Anterior Commissure
SCN
3rd Nucleus of the Anterior Hypothalamus
Differences in Brain Anatomy between Homo and Hetero: Hemisphere Size *Right hemisphere larger than left in hetero men
*Equal sizes in hetero women and homo men
*Homo females are intermediate
Differences in Brain Anatomy between Homo and Hetero: Amygdala *Left has more widespread connected than Right in hetero females and homo males
*Right has more widespread connected than Left in hetero males and homo females
*Homo females are intermediate
Differences in Brain Anatomy between Homo and Hetero: Anterior Commissure Gay men=straight women>straight men
Differences in Brain Anatomy between Homo and Hetero: SCN Gay men>straight men
-Rats deprived of testosterone during critical period have abnormal SCN and vary male/female preference throughout the day
Differences in Brain Anatomy between Homo and Hetero: 3rd Nucleus of the Anterior Hypothalamus *2x as large as in straight men as straight women
*Same size in gay men and straight women
*Neurons larger and more numerous in straight men
Differences in Brain Anatomy in regard to Transgender individuals ****Difference based on Gender Identity

*BNST (forebrain region) is larger in men than women
*No difference between heterosexual and homosexual men
*Small in male to female transsexuals (more similar to women)
*Large in female to male transsexuals (more similar to men)
=correlation is sexual identity no orientation
How do Hetero and Homo individuals differ in their response to Pheremones?*Hetero women and Homo men respond to AND (found in male sweat)- activation in preoptic area and ventomedial hypothalamus

*Hetero men respond to EST (found in female urine)- activation in paraventricular nucleus and dorsomedial nucleus of hypothalamus

*Lesbians respond to EST somewhat similarly to Hetero males. Also processed AND with main olfactory system rather than anterior hypothalamus
What the relevance of the data such as differences in bone length between gay and straight individuals? *Bone length in arms, hands, legs
-Longer in men than women
-Homo males shifted in female direction
-Homo females shifted in male direction
*This difference begins very early in development
*Reflects differences in overall development between gay and straight individuals
What are some pseurdohermaphrodite or intersexes? Intersex: individuals whose sexual development is intermediate or ambigious

Turner's Syndrome
Klinefelter's Syndrome
Congenital Adrenal Hyperplasia (CAH)
Androgen Insensitivity Syndrome
DHT Deficiency
Turner's Syndrome *Female in gender, Heterosexual
*Only 1 X= XO genotype
*Lack ovarian hormones
*Don't enter puberty
*Infertile
*98% spontaneously abort
Klinefelter's Syndrome *Male in gender, Heterosexual
*XXY genotype
*Internal sex is ok
*Small testes
*Low testosterone, low sperm
*Gynecomastia
Congenital Andrenal Hyperplasia (CAH)*Female in gender, Mixed sexual orientation but leans towards Heterosexual
*In XX (female)
*Autosomal recessive
*Too much testosterone during development
*Ok if XY, but if XX:
-Presence of DHT (made from testosterone) partially masculinizes the genitalia (and brain?)
-Ambiguous external genitalia (internal organs less affected)
-Usually diagnosed at birth
-Sometimes surgical intervention when discovered at birth
-Individual is treated with cortisol to reduce high concentrations of CRH and ACTH
-Childhood Behavior: intermediate between boy and girl
-Adult Behavior: compared to other women have fewer than average sexual encounters and fantasies, more physical aggression, less interest in infants, and more interested in male dominated occupations
*Minority of people with this are intersex
*other problems include delayed or precocious puberty
Androgen Insensitivity Syndrome (Aka Testicular Feminization)*Genetic male XY, Female gender identity, Heterosexual
*Mutation of X chromosome in the region encoding the endrogen receptor- this unresponsive to testosterone or DHT
*In the uterus testes are produced but undescended. This causes degeneration of Mullerian Ducts= no internal reproductive organs develop. Lack of DHT action feminized external genitalia

*At Birth:
-(if complete AIS): Baby appears to be female. Child raised as girl- female gender identity and heterosexual
-(if incomplete AIS): Baby predominantly male and is raised as a boy
*At puberty:
-Breasts enlarge, hips broaden but no menstrual cycle since no ovaries. Little public hair--->physical exam--->find out about disorder.

*Intervention can be taken now to remove internal testes and vaginal canal lengthened.
DHT Deficiency (Aka 5 alpha reductase deficiency)*Gentic male XY, gender identity is girl but behavior is tomboyish
*Fairly common in 1 isolated community in Dominican Republic
*Genetic mutation causing a defect in the enzyme 5a reductase results in low levels of DHT but normal Testosterone
*In utero:
-Testes formed but not descended
-Normal levels of Testosterone= development of Wolffian ducts and regression of Mullerian Ducts
-No DHT= feminization of external genitalia

*At birth:
-Baby appears to be female and child is raised as a girl

*At Puberty
-Very high levels of testosterone act to partially masculinize the genitalia. Gender identity usually reassigned.
Current advise given to parents with a baby whose sex is intermediate?*Be honest and do nothing without informed consent
*Identify as male or female based on predominant external genitalia
*Rear child as consistently as possible but be aware that the person will later be orientation towards males, females, both, or neither
*Do not preform surgery until person is old enough to be involved in the decision

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