The neurotransmitters dopamine, epinephrine, and norepinephrine, which are active in both the brain and the peripheral sympathetic nervous system. These three molecules have certain structural similarities and are part of a larger class of neurotransmitters known as monoamines.
vertebrate nervous system
brain, spinal chord, peripheral nerves that extend throughout the body
central nervous system CNS
brain and spinal chord
peripheral nervous system PNS
cranial and spinal nerves that connect he CNS to all tissues
a specialized cell that can receive information and transmit it to other cells
it communicates via an axon and synapse
afferent part of PNS
carries sensory information to the CNS
efferent part of PNS
carries information from the CNS to the muscles and glands
somatic motor division
executes conscious movements
comtrosl physiological functions
action potential trigger release of neurotransmitter
1. action potential arrives; triggers entry of CA2+
2. response to CA2+, synaptic vesicles fuse with presynaptic membrane, then release neurotransmitter.
3. ion channels, opens when neurotransmitter binds; ion flows cause change in postsynaptic cell potential.
4. ion channels will close as neurotransmitter is broken down or taken back up by presynaptic cell.
the ion needed to initiate the release of acetylcholine into the synapse:
part of parasympathetic division
mostly cholinergic (releases ACh)
sympathetic postganglionic neurons
noradrenergic; use NE as their neurotransmitter
sympathetic nervous system
originates in the thoracic regions of the spinal cord
innervates fight or flight response,
division of the autonomic nervous system that arouses the body, mobilizing its energy in stressful situations
parasympathetic nervous system
originates in the brain stem and lower part of the spinal cord, the division of the autonomic nervous system that calms the body, conserving energy
preganglionic sympathetic neurons
send axons to the adrenal glands
act on the same cell that secretes them
diffuse locally and act on neighboring cells
are hormones carried between cells by blood or other body fluids
diffuse a short distance between neurons
are release from neurons but are carried by blood or other body fluids and act on distant cells
are release into the environment and act differently on a different individuals
involved with autonomic regulation (relesed from presynaptic neurons) and also at the synapse with skeletal muscles (nicotinic ACH receptor is nAChR)
ex of a ligand gated ion channel
a real, physical property that can be measured
the MP of a cell is electrical potential inside minus the electrical potential outside, usually about -70 mV.
nicotinic receptors (nAChR)
or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons. Like the other type of acetylcholine receptors - muscarinic acetylcholine receptors (mAChRs) - the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). However, whereas muscarinic receptors are also activated by muscarine, nicotinic receptors are also opened by nicotine. Hence, the name "nicotinic".
depolarized the membrane of excitable cells and opens voltage gated ion channels
bind to ACh and open channels; are found on glands at every synapse of the sympathetic nervous system
ANS control internal process
parasympathetic nerves release ACh to promote "rest and digest"
sympathetic nerves release NE at organs to promote fight or flight
ME needs pacemaker activity via a b-adrenergenic receptor on teh cardiac muscle membrane that initiates a cascade to phosphorylate a calcium channel, ^ sensitivity to Vm
autonomic nervous system
the output of the of the CNS that controls involuntary functions
has two divisions that work in opposition:
sympathetic & parasympathetic
autonomic efferent pathways
being with cholinergic neurons that use ACh& have cell bodies in the brainstem or spinal chord
an encapsulated neural structure consisting of a collection of cell bodies or neurons outside of the CNS
1. E binds to receptors
2. action of g-protein
3. activated adenyl cyclase catalyzes formation of cAMP
4. activation of cAMP-dependant protein kinase A
The transfer of a phosphate group, usually from ATP, to a molecule. Nearly all cellular work depends on ATP energizing other molecules by phosphorylation.
sympathetic stimulation of cardiac muscle
Ne is released
NE binds to b-adrenergic receptors
receptor is a 7TMD protein, activates g-protein Gs
Gs activates adenyl cyclase, leads to production of cAMP
cAMP activates protein kinase A
PKA phosphoylates a calcium chaneel, speeding up the heartbeat by altering membrane sensitivity to changes in Vm
parasympathetic inhibition of cardiac muscle
Ach is released from postgangionic parasympathetic neurons
ACh binds to the muscarinic ACh receptor
receptos is a 7TMD protein that actiates a g-protein
a component of the activated g-protein binds then directly to a class of k channels, opening them.
does NOT involves phosphorylation
resting membrane potential results from:
uneven distribution of ions across the cell membrane
excitable cells: how they work
1. at rest; cell membranes hve nonequilibrium Vm so that voltage gated channels can generate and propagate action potentials.
2. a AP is a large and rapid all or non change in Vm involving depolarization of the membrane due to changes in permeability of the membrane to ions and currents via voltage gated channels
3. ACh and NE can act as chemical messengers to initiate an AP at chemical synapses between a presynaptic autonomic nerve cell and post synaptic target organ cells
4. vascular smooth muscle cells can also respond to signals that do not change membrane potential
is potassium in equilibrium in a typical animal cell?
equilibrium for an ion is NOT equal concentrations
excitable cells at rest have a nonequilibriu, so that voltage-gated channels can generate and propogate AP's.
muscle and nerve cells are excitable!
calcium as a signal
the resting level of Ca2+ in cytoplasm is far below equilibrium, about 200 nM
cytoplasmic Ca2_ often increases dramatically in response to external signals
cells have powerful mechanism for rapidly restoring the resting level of CA2+ after signal
there are two mechanisms for rapidly increasing CA2+ in cells
-calcium can enter the cytoplasm from outside via plasma membrane calcium channel
a small, nonprotein, water-soluble molecule or ion, (such as calcium ion or cyclic AMP, IP3) that relays a signal to a cells interior in response to a signal received by a signal receptor protein.
any of various peripheral membrane proteins that bind GTP & function in signal transduction: binding of a signal to its receptor triggers activation these proteins, leading to production of a second messenger or start of phosphoylation cascade
when calcium becomes available inside a cell, it comes from:
intracellular storage & extra cellular fluid