1.
Antipsychotics MOA: D2 receptor blocking
2.
Anxiety: Benzodiazepines, Buspirone, SSRIs
3.
Atypical antipsychotics: Block 5HT-2 and D2 receptors
4.
Atypical antipsychotics mneumonic: Its ATYPICAL for OLd CLOZets to QUIETly RISPER from A to Z
(Olanzapine, Clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)
5.
Atypical depression: MAOI, SSRIs
6.
Bipolar: Lithium, valproic acid, carbamazapine
7.
Bupropion: Atypical Antidepressant and for smoking cessation; increased NE and Dopa; no sex SEs
8.
Buspirone: Stimulates 5HT-1A receptors. Used for anxiety. Not addictive
9.
Clinic use of Lithium: Mood stabilizer, blocks relapse and acute manic events. Also SIADH
10.
Depression: SSRIs, SNRIs, TCAs
11.
Depression with Insomnia: Trazodone, Mirtazapine
12.
Duloxetine: SNRI - depression and diabetic peripheral neuropathy
13.
Evolution of Extrapyramidal symptoms: 4 h acute dystonia, 4 d akinesia (Parksinsonian Sx), 4 wk akathisia (restlessness), 4 mo. tardive dyskinesia (caused by activation of the nigrostriatal pathway)
14.
High potency neuroleptics: Haloperidol, trifluoperizine (more neurologic side effects)
15.
Lithium MOA: Inhibit phosphoinositol cascade
16.
Lithium side effects: (LMNOP) Movement (tremors), Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems
17.
Low potency neuroleptics: Chlorpromazine (Corneal deposits), Thioridazine (reTinal deposits)
18.
MAO-I's MOA: Increase levels of amine NT's
19.
Maprotiline: Antidepressant, NE reuptake blocker
20.
Methylphenidate: Increase release of NE
21.
Mirtazapine: Antidepressent. Alpha2 antagonist, 5HT-2 and 5HT-3 antagonist.
22.
Neuroleptic Malignant syndrome (NMS): Rigidity, myoglobinuria, ANS instability, pyrexia
"FEVER" - Fever, Encephalopathy, Vitals unstable, Elevated enzymes, Rigidity of muscles
23.
OCD: SSRIs, Chlomipramine
24.
Panic Disorder: SSRI, TCA, Benzodiazepines
25.
Schizophrenia: Antipsychotics (have excess dopamine)
26.
Serotonin syndrome: Hyperthermia, muscle rigidity, cardiovascular collapse
27.
Side effect of Clozapine: Agranulocytosis (weekly WBC monitoring), seizures
28.
Side effects: Neuroleptic malignant syndrome, Extrapyramidal symptoms, galactorhhea; muscarinic alpha and histamine blocking effects
29.
Side effects of MAO-I's: Hypertensive crisis with Beta blockers and tyramine. Serotonin syndrome with SSRIs or meperidine.
30.
Side effects of Ziprasidone: may prolong QT interval
31.
SNRIs: -Venlafaxine, duloxetine
-MOA: inhibits NE > 5HT reuptake
-SE: increase BP
32.
Social phobias: SSRI
33.
SSRI MOA: Block reuptake of serotonin
34.
SSRI side effects: Serotonin syndrome with MAO-Is
35.
TCA side effects: Sedation, anticholinergic
36.
Tourettes: Antipsychotics (haloperidol, resperidone)
37.
Toxicity of TCAs: "tri-C's" Convulsion, Coma, Cardiotoxicity
also hallucination in elderly
Rx: NaHCO3 for CV toxicity
38.
Trazodone: - inhibits 5-HT reuptake
- treats insomnia
- SE: priapism "TrazoBONE"
39.
Treatment for NMS: Dantrolene or dopamine agonists (bromocriptine)
40.
Tricyclic antidepressants MOA: Block reuptake of NE and serotonin
41.
Use of atypical psychotics in schizophrenia: Treat positive and negative symptoms
42.
Venlafaxine: SNRI - depression and GAD