| Term | Definition |
| obsolete | outmoded |
| obstetrician | physician specialised in delivery of babies |
| obstinate | stubborn |
| obstreperous | boisterous; noisy |
| obtrude | intrude; push forward idea on others; extrude |
| obtuse | blunt; stupid |
| obviate | make unnecessary; get rid of |
| occident | the west |
| occlude | shut; close |
| occult | mysterious; secret; supernatural |
| oculist | physician who specializes in treatment of eyes |
| odious | hateful |
| odium | hatefulness |
| odoriferous | giving off an odor |
| odorous | having an odor |
| odyssey | long eventful journey |
| offensive | attacking; insulting; distasteful |
| offhand | casual; done without prior thought |
| officious | meddlesome; excessively pushy in one's services |
| ogle | look at amorously; make eyes at |
| olfactory | concerning the sens of smell |
| oligarchy | government by a privileged few |
| ominous | threatening |
| omnipotent | all-powerful |
| omnipresent | universally present |
| omniscient | all knowing |
| omnivorous | eating both plant and animal food |
| onerous | burdensome |
| onomatopoeia | word formed in imitation of natural sounds |
| onslought | vicious assault |
| onus | burden; responsibility |
| opalescent | iridescent; lustrous |
| opaque | dark; not transparent |
| opiate | medicine to induce sleep or deaden pain |
| opportune | well-choosen; timely |
| opportunist | individual who sacrifices principles for expediency by taking advantage of circumstance |
| opprobrium | infamy; vilification |
| optician | maker and seller of eyeglasses |
| optimist | person who looks on the bright side |
| optimum | most favourable |
| optional | not compulsary |
| optometrist | one who fits glasses to remedy visual defects |
| opulence | extreme wealth; luxuriousness; abundance |
| opus | work |
| oracular | prophetic; uttered as if with devine authority |
| orator | public speaker |
| oratorio | dramatic poem set to music |
| ordain | decree or command; grant holy orders |
| ordeal | severe trail or affliction |
| ordinance | decree |
| ordination | ceremony conferring holy orders |
| orgy | wild; drunken revelry; unrestrained indulgence |
| orient | get one's bearings; adjust |
| orientation | act of finding oneself in society |
| orifice | mouthlike opening; small opening |
| ornate | excessively or elaborately decorated |
| ornithologist | scientific student of birds |
| orthodox | traditional; conservative in belief |
| orthography | correct spelling |
| oscillate | vibrate pedulumlike; waver |
| ossify | change or harden into bone |
| osseous | made od bone; bony |
| ostensible | apparent; professed; pretended |
| ostentatious | showy; pretentious |
| ostracize | ban; exclude from public favor |
| oust | expel |
| outlandish | bizarre; unconventional; peculiar |
| outmoded | no longer stylish; old-fahioned |
| outskirts | fringes; outer borders |
| outspoken | candid; blunt |
| outstrip | surpass; outdo |
| outwit | outsmart; trick |
| ovation | enthusiastic applause |
| overbearing | bossy; arrogant; decisively important |
| overt | open to view |
| overweening | presumptuous; arrogant |