Use in rheumatoid arthritis, asthma, brain swelling, etc. Inhibits inflammatory response, suppresses T cell proliferation and activation, suppress Ab production. Activates transcription of glucocoricoid response elements.
Inhibits the calcineurin phosphatase and T cell activation. Blocks IL-2 production. Used to prevent graft vs host syndrome. Some nephro and hepatotoxicity.
Like cyclosporine it blocks IL-s production and T cell activation. It is 100X more potent than cyclosporine; therefore, the toxicity effects are similar, but more severe.
Immune sppressing drug that does not block IL-2 production. This drug may produce a tolerance (a good thing with immunodrugs). Also inhibits T cell activation.
Used in combination with corticosteroids for immunosuppression. Converted to a competative inhibitor if inosinic acid (precursor to A and G); therefore, it blocks the cell cycle in the S phase. Coadministration of allopurinol can increase toxicity effects (in the GI, bone marrow, and liver).
Inhibits monophosphate dehydrogenase; therefore blocks synthesis of purines as well as B and T lymphocytes. Used with cyclosporine and corticosteroids to prevent rejection of transplant. Coadministration with antacids including MG and Al decreases absorption.
Sphingosine-phosphate receptor agonist. Sequesters lymphocytes in lymph nodes and peyer's patches, thus protecting a graft from T-cell attack. Used with cyclosporine and prednisone to inhibit rejection. Can increase the heart rate of a patient with 1st dose. Must be careful with patients with heart disease.
Boost immune functioning for use in treating conditions like Kaposi sarcoma or hairy cell leukemia. Lots of potential effects from toxicity.
Induces a T-cell response. Good for use on malignancies like renal cell cancer. Lots of potential toxicity effects.
Mouse/human clonal Ab that blocks the IL-2 receptor on T lymphocytes; thus suppressing the immune response. Often given with cyclosporine and corticosteroid. No real toxicity effects!
Mouse monoclonal Ab. Binds to CD3 on T lymphocytes... due to the proximity of CD3 to the TCR complex, this is blocked as well. The T cell is unable to identify any antigens and cannot then attack the graft. Toxicity leads to cytokine release syndrome which can include life threatening pulmonary edema.
Ab binds to TNFa and prevents the cytokine from binding its receptor. Immunosuppressant. May also be used in Crohn's Disease.
Like infliximab, this drug binds to TNFa and prevents it from binding to its receptor and mediating an immune response.
A viable strain of mycobacterium that stimulates the actions of NK cells and T cells. Useful for bladder cancers. Toxicity can lead to severe hypersensitivity (because it is a natural bacteria).
Expands the population of neutrophil granulocyte precursors. Can cause bone pain in back, sternum, and pelvis from toxicity. AKA granulocyte colony-stimulating factor (G-CSF)