| Term | Definition |
|---|
| cromolyn sodium | Like nedocromil, inhibits release of histamine by inhibiting immunologically triggered release from mast cells. |
| nedocromil | Like cromolyn sodium, inhibits realease of histamine from immunologically triggered release from mast cells. |
| chlorpheniramine | H1 receptor blocker, that is part of the first generation of H1 blockers; therefore, also causes sedation in the CNS... though not nearly as much as Benadryl. |
| diphenhydramine | First generation H1 receptor blocker... causes significant sedation. Can be used in motion sickness and Parkinson's because of its anticholinergic effects. |
| fexofenadine | 2nd generation H1 receptor blocker: no sedation and a lower risk of cardiac problems. |
| loratidine | 2nd generation H1 receptor blocker: no sedation, no cardiac effects and longer action than fexofenadine. |
| promethazine | 1st generation H1 receptor blocker: causes significant sedation. Can also have effects against motion sickness... NOT BENADRYL. |
| terfenadine | An H1 blocker that interacts poorly with antibiotics that inhibit CYP450. Causes cardiac problems with increased toxicity. Was replaced by 2nd generation H1 blockers because of dangerous cardiac effects. |
| cimetidine | H2 receptor antagonist used to treat heartburn, ulcers, and excessive acid. It is well tolerated, but inhibits the actions of CYP450. No effects on GI mobility or any significant anticholinergic effects. |
| ranitidine | H2 receptor antagonist that is well tolerated and does NOT inhibit CYP450... this one begins with an "r" |
| famotidine | H2 receptor antagonist that is well tolerated and does NOT inhibit CYP450... this one begins with an "f" |
| nizatidine | H2 receptor antagonist that is well tolerated and does NOT inhibit CYP450... this one begins with an "n" |
| omeprazole | Proton pump inhibitor that is much more potent for acid reduction than H2 receptor antagonists. Inhibits CYP450. It is activated by acid in the stomach; therefore, one should refrain from taking an antacid until one has already taken this drug. Long term use (>8wks) is not advisable. |
| sucralfate | Nonabsorbable complexes of AlOH and sucrose sulfate... forms a protective gastric barrier over ulcers. The drug is activated by gastric acid. |
| sulfasalazine | Made up of 2 parts which are split by bacteria in the colon. 50ASA inhibits inflammatory mediator synthesis, and sulfapyridine is responsible for side effects (but is required to deliver the drug to the colon). Useful in ulcerative colitis and crohn's disease. |
| infliximab | Monoclonal antibody against TNFa (immunosuppressant). Generally well tolerated. |
Combine with other sets
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