cause respiratory tract infections, conjunctivitis, gastroenteritis, and hemorrhagic cystitis
aka conjunctivitis, it is inflammation of the conjunctiva of the eye
inflammation of urinary bladder with hemorrhage.
Coxsackie adenovirus receptor
receptor used by many Coxsackie B viruses; this receptor allows the viral fiber proteins to interact with a glycoprotein member of the immunoglobulin superfamily of proteins
E1A, E1B proteins
E1A is an oncogene, together with E1B proteins can stimulate cell growth by binding to the cellular growth surpressor proteins p105RB
p105RB retinoblastoma gene product, p53
cellular growth-suppressor proteins that promotes transformation
lytic, latent, persistent, transforming
Adenoviruses are capable of causing these type of infections: lytic is mucoepithelial, latent is lymphoid and adenoid cells, and transforming refers to hamsters
space between the envelope and the capsid
immediate early (α) proteins
consist of proteins important for the regulation of gene transcription and takeover of the cell
early (β) proteins
.consist of more transcription factors and enzymes including DNA polymerase
late (γ) proteins
consist mainly of structural proteins which are generated after viral genome replication has begun
during a latent infection of neurons it is the only region of the genome to be generated. These RNAs are not translated into protein.
Cowdry type A acidophilic intranuclear inclusion bodies
produced by HSV through changes in the nuclear structure and margination of the chromatin.
multinucleated mass of cytoplasm that is not separated into individual cells caused by HSV
occurs upon reactivation and vesicle fluid contains infectious virions.
when an infection or virus reactivation occurs due to a trigger like stress
cold sores, fever blisters
are recurrent HSV mucocutaneous infections after the primary infection is gone
Inflammation of the cornea or of the cornea and conjunctiva almost aways limted to one eye.
herpes infection of the body
herpes infection of the finger
a generalized vesiculopustular rash caused by herpes simplex. Acquired by children with active eczema; Kaposi's varicelliform eruption
typically from HSV2 but herpes open sores on the genitals of both males and females
cause lesions on the temporal lobe from HSV1
complication of genital HSV-2 infection; symptoms resolve by themselves.
acyclovir, valacyclovir, penciclovir, famciclovir
are drugs that treat HSV
phosphorylate ACV and penciclovir to activate the drug as a substrate for the viral DNA polymerase.
itchy rash you get as a kid from the varicella virus
classic childhood exanthems
chicken pox, rubella, roseola, fifth disease, and measles
herpes zoster, shingles
.vesicular rash along the entire dermatome. A recurrence of a latent varicella infection acquired earlier in the patient's life.
a chronic pain syndrome caused by shingles
varicella zoster immunoglobulin, it is preventative only, wont help if you actively have the disease
endemic burkitt lymphoma cuased by epstein barr virus
malignant lymphoma caused by Epstin-barr virus
malignant tumor arising in the epithelial lining of the nasopharynx cased by Epstein-barr virus
DNA binding proteins that are essential for establishing and maintaining the infection, immortalization and other purposes
an IgM antibody to the Paul Bunnell antigen
contagious illness caused by EBV. Results from a "civil war" between the EBV-infected B cells and the protective T cells.
increase in mononuclear cells
T cells that appear as atypical lymphocytes
is an enlargement of the spleen
posttransplant lymphoproliferative disease
disease transplant recipients undergoing immunosuppressive treatment are susceptible to.
cytomegalic inclusion disease
series of signs and symptoms caused by cytomegalovirus infection (small size, thrombocytopenia, microcephalay, intracerebral calcification, jaundice, hepatosplenomegaly, and rash)
heterophile-negative mononucleosis syndrome
mononucleosis-like symptoms caused by cytomegalovirus that result in negative heterophile antibody test
ganciclovir, valganciclovir, cidofovir, foscarnet
treats diseases caused by cytomegalovirus infections
.aka roseola. Common disease of children associated with HHV6.
form of skin cancer caused by Human herpesvirus 8 (HHV8)
primary effusion lymphoma
a B-cell lymphoma associated with human herpesvirus 8 infection, characterized by the occurrence of lymphomatous effusions in body cavities without the presence of a solid tumor
multicentric Castleman disease
uncommon lymphoproliferative disorder that involves growths at multiple sites
aka small pox
wartlike lesion spread from direct contact with the lesion caused by poxvirus
localized lesion from poxvirus of sheep and goat
localized lesion from rodents, cats, and cows (vaccinia)
only known parvovirus to cause human disease
aka fifth disease, caused by B19, is a mild febrile exanthematous disease
chronic hemolytic anemia aplastic crisis
when a patient has sickle cell anemia and is infected with B19 causes a life threatening reticulocytopenia
Adeno associated viruses, are dependoviruses that need a helper virus like adenoviruses to cause disease
Parovirus B19 has two phases that is called ______.
(1) Initial febrile stage - the infectious stage where erythrocyte production stops and large viremia w/nonspecific flulike symptoms occurs.
(2) Symptomatic stage - immune mediated stage where rash, arthralgia, and arthritis occurs.
Parvovirus B19 causes this condition in which the virus infects a fetus and kills erythrocyte precursors, causing anemia and CHF. Infection in a seronegative mother can increase risk of fetal death.
This virus two types - A &B. "A" causes vesicular lesions (i.e. herpangina). "B" causes myocarditis and pleurodynia. Also causes polio-like paralytic disease.
An enterovirus that is derived from enteric cytopathic human orphan. Causes viral aseptic meningitis.
The Picornaviridae classification of poliovirus, coxsackie A & B, echovirus, and enterovirus. This class of viruses are resistant to harsh environmental conditions esp. in the GI tract which facilitates their fecal-oral route transmission.
Causes the common cold and upper respiratory tract infections. Uses a common receptor called ICAM-1.
A picornavirus with 3 serotypes. Causes polio.
is the loss of neurons that result in paralysis later in life
AKA Major illness. Most severe form of disease caused by the polio virus. A neural infection that appears after minor illness (AKA Abortive poliomyelitis).
Poliovirus infection that involves muscles of the pharynx, vocal cords, and respiration. Iron lungs (chambers that provided external respiratory compression) used to assist breathing.
A vesicular exanthem caused by Coxsackievirus A16. Vesicular lesions on the hands, feet, and mouth. Results in a mild fever and resolves in a few days.
caused by the coxsackie virus NOT herpes and is ulcers on the soft palate and uvula
inactivated and the live attenuated oral polio vaccine
reducing the virulence of a pathogen, but still keeping it alive
Rhinoviruses + Coxsackieviruses have this receptor. Member of the immunoglobulin superfamily, which is expressed on epithelial, fibroblast, and B-lymphoblastoid cells.