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5 Written questions

5 Matching questions

  1. Cells isolated from breast and colon cancer have accumulated ~1 amino acid change in 100 different proteins, but alterations in only 20 of these genes are likely needed for tumor progression
  2. Telomerase
  3. 1. Cells that make up the supporting connective tissue (fibroblast cells)
    2. Inflammatory white blood cells, and
    3. Vascular epithelial cells
  4. No
  5. A
  1. a Is it only the accumulation of a large number of mutations that gives rise to a tumor?
  2. b Tumorigenesis requires the assistance of other cell types. What are they?
  3. c What evidence supports the fact that it is not simply the accumulation of large number of mutations that gives rise to a tumor?
  4. d What enzyme complex is responsible for maintaining the ends of chromosomes?
  5. e
    Which picture shows normal epithelium (of the cervix)?

5 Multiple choice questions

  1. An increase in cell division gives rise to an increased chance that one of these cells will undergo an additional mutagenic or epigenetic change further promoting the progression towards what?
  2. Even for cancers associated with a known external agent, the time of onset is what?
  3. The inherited pattern of DNA methylation reinforces gene silencing events established by the packaging of DNA into what?
  4. The formation and maintenance of inappropriate heterochromatin may result from what?
  5. Development of cancerous cells can take how long?

5 True/False questions

  1. Benign tumorThe rate of mutation is balanced against what?


  2. Mutations that inactivate cell cycle checkpointsContinued cell division with unrepaired and/or missegregated DNA is due to the acquisition of what? That inactivate what?


  3. YesDo normal cells have a llimited number of times they can divide?


  4. 25-50 divisionsWhat process makes a 'tumor' a 'cancer'?


  5. It exits the blood/lymphatic vessel and establishes growth at this new locationThe single cell that causes cancer experienced a heritable change that was followed by additional changes in one of its descendents. These changes allowed the cells to do what?


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