5 Written questions
5 Matching questions
- Cells isolated from breast and colon cancer have accumulated ~1 amino acid change in 100 different proteins, but alterations in only 20 of these genes are likely needed for tumor progression
- 1. Cells that make up the supporting connective tissue (fibroblast cells)
2. Inflammatory white blood cells, and
3. Vascular epithelial cells
- a Is it only the accumulation of a large number of mutations that gives rise to a tumor?
- b Tumorigenesis requires the assistance of other cell types. What are they?
- c What evidence supports the fact that it is not simply the accumulation of large number of mutations that gives rise to a tumor?
- d What enzyme complex is responsible for maintaining the ends of chromosomes?
Which picture shows normal epithelium (of the cervix)?
5 Multiple choice questions
- An increase in cell division gives rise to an increased chance that one of these cells will undergo an additional mutagenic or epigenetic change further promoting the progression towards what?
- Even for cancers associated with a known external agent, the time of onset is what?
- The inherited pattern of DNA methylation reinforces gene silencing events established by the packaging of DNA into what?
- The formation and maintenance of inappropriate heterochromatin may result from what?
- Development of cancerous cells can take how long?
5 True/False questions
Benign tumor → The rate of mutation is balanced against what?
Mutations that inactivate cell cycle checkpoints → Continued cell division with unrepaired and/or missegregated DNA is due to the acquisition of what? That inactivate what?
Yes → Do normal cells have a llimited number of times they can divide?
25-50 divisions → What process makes a 'tumor' a 'cancer'?
It exits the blood/lymphatic vessel and establishes growth at this new location → The single cell that causes cancer experienced a heritable change that was followed by additional changes in one of its descendents. These changes allowed the cells to do what?