a complex of ribonucleoproteins that catalyze the removal of introns from pre-mRNA
small nuclear ribonucleoprotines - part of spliceosome
snRNPs are made up of: - and -
vary in nucleotide composition
U1, U2, U4, U5, U6
binds to 5' splice site; joins prior to lariat formation; leaves prior to lariat formation
binds branch-point sequence; binds to U6
interacts with U6; leaves before splicing
no complement to snRNA or exon/intron; interacts with last base of 1st exon AND first base of 2nd exon; involved in positioning; in a complex with U6/U4
binds to 5' splice site; joins before lariat forms; stays after lariat for splicing; interacts with U4/U2; only interacts with U4 OR U2
_ _:U1 binds at the 5' splice site
A complex; ATP
_ _:U2 binds to the branch point in intron (A); folds the pre-mRNA; requires _
_ _: U6/U4/U5 bind to 5' splice site; allows U5 to interact with the last base/first base
U4; U6; U1
the spliceosome is activated, using ATP, when _ leaves the complex and _ displaces _
_ _: using ATP, U2 and U6 interact
_ _: lariat intermediate forms
_ _: using ATP, exons are joined and intron is removed
_ _: introns only, exons excised
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