5 Written Questions
5 Matching Questions
- Co-activator proteins
- Small molecule inhibitors of oncogene activity
- Block gleevec binding, eliminating the drugs effectiveness
- Ensuring that all cancerous cells have been removed
- Overexpress particular proteins
- a Because of the inherent genomic instability in cells in the acute phase of myeloid leukemia, secondary mutations in the kinase domain accumulate which block what? Do what to the drugs effectiveness?
- b What is another approach for the treatment of cancer?
- c In the nucleus of normal cells, the estrogen-estrogen receptor complex interacts with what?
- d What is the major difficulty of treating cancer?
- e Additional treatments for breast cancer take advantage of the fact that some cancerous cells do what?
5 Multiple Choice Questions
- What are two current treatment regimes for breast cancer?
- Estrogen activates cell proliferation, therefore cells that contain mutations in tumor suppressor genes or
oncogenes within target tissue can be what by the action of circulating estrogen
- Treatment of chronic myelogenous leukemia focused on the
identification of synthetic drug molecules that inhibits what?
- Tamoxifen treatment only works on cancerous cells that are what?
- Cancer treatments also target the destruction of blood vessels since what is dependent on the nutrient supply by these vessels?
5 True/False Questions
No → Does a change in the conformation of the tamoxifen-estrogen complex occur?
Cell proliferation → Estrogen activates what?
Transcriptional activation → What is blocked?
Treatment with both drugs at the same time has a higher likelihood of eliminating all cancerous cells reducing the probability of developing resistant cells → Sequential treatment leads to what two problems?
The signal for cellular proliferation → Estrogen activates what?