5 Written Questions

1. In normal cells, conformational change in the receptor-ligand complex initiates what?
2. Additional treatments for breast cancer take advantage of the fact that some cancerous cells overexpress particular proteins. Targeting these proteins selectively blocks what?
3. Tamoxifen targets the estrogen receptor by binding what?
4. 
   Gleevec sits in the ATP-binding pocket of the Abl tyrosine kinase preventing what?
5. The maintenance of DNA sequences are essential for what?

5 Matching Questions

1. Co-activator proteins
2. Small molecule inhibitors of oncogene activity
3. Block gleevec binding, eliminating the drugs effectiveness
4. Ensuring that all cancerous cells have been removed
5. Overexpress particular proteins

1. a Because of the inherent genomic instability in cells in the acute phase of myeloid leukemia, secondary mutations in the kinase domain accumulate which block what? Do what to the drugs effectiveness?
2. b What is another approach for the treatment of cancer?
3. c In the nucleus of normal cells, the estrogen-estrogen receptor complex interacts with what?
4. d What is the major difficulty of treating cancer?
5. e Additional treatments for breast cancer take advantage of the fact that some cancerous cells do what?

5 Multiple Choice Questions

1. What are two current treatment regimes for breast cancer?
   1. 1. Blockage of estrogen receptors (tamoxifen)
      2. Down regulation of estrogen synthesis
      3. Monoclonal antibody inhibition of Her2 protein
      (oncogene addition)
      4. Antibody deliver of toxic molecules
   2. Estrogen receptors on the plasma membrane
   3. 1. Blockage of estrogen receptors (tamoxifen)
      2. Down regulation of estrogen synthesis
   4. The estrogen receptor or the synthesis of estrogen
2. Estrogen activates cell proliferation, therefore cells that contain mutations in tumor suppressor genes or
   oncogenes within target tissue can be what by the action of circulating estrogen
   1. Amplified
   2. Gleevec
   3. Tamoxifen
   4. Viability
3. Treatment of chronic myelogenous leukemia focused on the
   identification of synthetic drug molecules that inhibits what?
   1. The activity of the Abl tyrosine kinase
   2. Co-activating proteins
   3. Co-activator proteins
   4. A hyperactive form of the Abl tyrosine receptor
4. Tamoxifen treatment only works on cancerous cells that are what?
   1. Their transcription
   2. Co-activator proteins
   3. The receptor
   4. Estrogen receptor positive
5. Cancer treatments also target the destruction of blood vessels since what is dependent on the nutrient supply by these vessels?
   1. The receptor
   2. Her2
   3. Tumor growth
   4. Tamoxifen

5 True/False Questions

1. No → Does a change in the conformation of the tamoxifen-estrogen complex occur?

   True        False

2. Cell proliferation → Estrogen activates what?

   True        False

3. Transcriptional activation → What is blocked?

   True        False

4. Treatment with both drugs at the same time has a higher likelihood of eliminating all cancerous cells reducing the probability of developing resistant cells → Sequential treatment leads to what two problems?

   True        False

5. The signal for cellular proliferation → Estrogen activates what?

   True        False