Cecil - Chp 17 - 02

5 Written Questions

1. diaphoretic↓FEV1, bronchoprovocation challenge (methacholine, cold-air)
2. clinical triad (sinusitis, situs inversus, infertility)
3. meconium ileus, steatorrhea, salty-tasting skin, pancreatic insufficiency, malasborption, azoospermia
4. multidrug resistant Burkholderia cepacia
5. TH2-predominant T-cell response

5 Matching Questions

1. bronchiectasis (radio)
2. bronchiolitis obliterans syndrome
3. diffuse panbronchiolitis
4. bronchiolar disorders
5. CTFR mutation

1. a after lung transplantation
2. b defective chloride transport, ↑Na absorp (airway, thick mucus) exocrine dysfunction
3. c patchy inflammation/epithelial injury, fibrosis of bronchioles (noncartilaginous)
4. d in Japan, cough w/ purulent sputum
5. e tram track shadows (thickened bronchial walls)

5 Multiple Choice Questions

1. RSV
   1. acute bronchiolitis
   2. bronchiectasis
   3. CTFR mutation
   4. diffuse panbronchiolitis
2. Azithromycin
   1. cystic fibrosis (treatment)
   2. bronchiolitis obliterans syndrome
   3. bronchiectasis (younger pts)
   4. bronchiolitis obliterans syndrome (treatment)
3. sweat test > 60 mEq/L (chloride, two occasions)
   1. cystic fibrosis
   2. cystic fibrosis (treatment)
   3. cystic fibrosis (diagnosis)
   4. cystic fibrosis (clinical)
4. airway inflammation, airway hyper-reactivity, reversible airflow obstruction
   1. asthma (hallmark)
   2. CTFR mutation
   3. Asthma
   4. asthma (clinical)
5. autosomal recessive, multi-organ (lung, pancrease, repro), CFTR defect
   1. bronchiectasis
   2. cystic fibrosis (clinical)
   3. cystic fibrosis
   4. advanced cystic fibrosis

5 True/False Questions

1. cystic fibrosis (treatment) → pancreatic enzy replacement, antibiotics, bronchodilators, dornase alfa (sputum), inhaled tobramycin (pseudomal)

   True        False

2. bronchiectasis (cause) → tram track shadows (thickened bronchial walls)

   True        False

3. bronchiectasis (younger pts) → bacterial, viral, allergic bronchopulmonary aspergillosis

   True        False

4. bronchiectasis (clinical) → chronic cough, foul-smelling sputum

   True        False

5. bronchiolar disorders (diagnosis) → HRCT (tree-in-bud opacities)

   True        False