exam3
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solidliquidgas Plus on April 12, 2012
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99 terms
Terms | Definitions |
|---|---|
 mGluR structure, TM, hill coeff., how many g protein binding | homodimer, 7TM, hill=1, 1-2 g protein binding |
| Non NMDA function as | Na channels |
| NMDAR function as | Ca channels |
| G protein coupled receptor I | excitatory increase PLC activity |
| G protein coupled receptor II | inhibitory decrease AC activity |
| mGLuR class I | mGluR1,5 increase IP3 and Ca2+ |
| mGluR class II | mGluR2,3 decrease cAMP |
| mGluR class III | mGluR4,6,7,8 decrease cAMP |
| mGluR class I competitive agonist | Glu Ibotenic acid DHPG ACPD HCPCC CHPG quisqualate |
| mGluR class I competitive antagonists | EMQMCM MPEP, MTEP |
| DHPG | mGluR class I competitive agonist |
| ACPD | mGluR class I competitive agonist |
| HCPCC | mGluR class I competitive agonist |
| Ibotenic acid | mGluR class I competitive agonist |
| quisqualate | mGluR class I competitive agonist |
| CHPG | mGluR class I competitive agonist |
| mGluR class II agonists | Glu NAAG APDC DCC |
| mGluR class II competitive antagonist | EthGlu |
| NAAG | mGluR class II agonists |
| APDC | mGluR class II agonists |
| DCC | mGluR class II agonists |
| EthGlu | mGluR class II competitive antagonist |
| mGluR class III comp. agonists | Glu AP4 |
| mGluR class III comp. antagonists | MAP4 |
| MAP4 | mGluR class III comp. antagonists |
| AP4 | mGluR class III comp. agonist |
| ACh biosynthesis | Acteyl CoA + choline (ChAT) ACh + CoA |
| ACh degradation | ACh (AChE) acetate + choline |
| Organophosphate (Anti cholinesterase) | Sarin IRREVERSIBLE DDT IRREVERSIBLE Diazinon REVERSIBLE Malathion REVERSIBLE |
| Sarin | Organophosphate (Anti cholinesterase) IRREVERSIBLE |
| DDT | Organophosphate (Anti cholinesterase) IRREVERSIBLE |
| Diazinon | Organophosphate (Anti cholinesterase) REVERSIBLE |
| Malathion | Organophosphate (Anti cholinesterase) REVERSIBLE |
| Clinical anti-cholinesterase | Donepezil Physostigmine |
| Donepezil | Clinical anti-cholinesterase |
| Physostigmine | Clinical anti-cholinesterase |
| Regenerator of AChE | Abidoxime |
| Abidoxime | Regenerator of AChE |
| What has inhibitory effect on VAChT | Vesamicol Inhibits ACh uptake and reduces its release |
| 5 classes of mAChRs | M1,3,5: Gq M2,4: Gi |
| Brucine | enhance muscarinic agonist binding |
| mAChR agonists | ACh, Carbachol Muscarine Oxotremorine Pilocarpine (M1) |
| Carbachol | mAChR agonists |
| Oxotremorine | mAChR agonists |
| Muscarine | mAChR agonists |
| Pilocarpine | mAChR agonist (M1) |
| mAChR antagonists | Atropine Scopolamine cyclopentolate pirenzepine (M1) aclidinium (M3) tropicoamide (M4) himbacine (M2,4) gallamine (M2) |
| Atropine | mAChR antagonists |
| Cyclopentolate | mAChR antagonists |
| Scopolamine | mAChR antagonists |
| Pirenpazine | mAChR antagonists (M1) |
| Aclidinium | mAChR antagonists (M3) |
| Tropicoamine | mAChR antagonists (M4) |
| Himbacine | mAChR antagonists (M4,2) |
| Gallamine | mAChR antagonists (M2) |
| Afterpolariziation Ca spike is mediated by | M1, M3 mAChRs |
| Block of HVA VDCCs can be mediated by | M1, M3R Gq alpha subunit |
| Extremely slow IPSPs via | M2 mAChRs GIRKS: beta gamma subunits |
| Im block by muscarinic agonists is mediated by | Gq alpha subunit |
| Anti-AChEs block slow AHPs via | M1, M5 AChRs |
| Catecholamine synthesis | Tyr (TH)-rate limiting enzyme DOPA (AAADC) DA (D beta H) NE (PNMT) EPI |
| Carbidopa | inhibits AAADC |
| TH sites | one phosphorylated by PKA and PKC one phosphorylated by CaM KII-PO4 |
| DA degradation 1 | DA (COMT) 3-methyl tyramine (MAO) HVA |
| DA degradation 2 | DA (MAP+aldehyde deOH) DOPAC (COMT) HVA |
| VDAT TM | 12TM |
| DA vesicular transport inhibitor | reserpine |
| reserpine | DA vesicular transport inhibitor |
| DAT inhibitor | Indatropline, Cocaine buproprion, nomifensine amineptine, methylphenidate, amphetamine |
| amineptine | DAT inhibitor |
| amphetamine | DAT inhibitor |
| methylphenidate | DAT inhibitor analog of amphetamines |
| analogs of amphetamines | methylphenidate phenmetrazine cocaine MDMA (ecstacy) |
| MDMA | analogs of amphetamines |
| What increases synpatic DA? | amphetamines |
| DA neurotoxin | MPTP MPP 6-OH-DA |
| MPP | DA neurotoxin |
| 6-OH-DA | DA neurotoxin |
| MPTP | DA neurotoxin |
| DARs TM | 7TM |
| DARs types | D1,2,3,4,5 |
| D1 alpha subunit, | Gs |
| D2,3,4 alpha subunit | Gi |
| D5 alpha subunit | Gs |
| D2 beta gamma subunit | decreases CDCC, VDKC, CDKC |
| DA agonists | Dopamine Apomorphine Dihydroxidine Bromocriptin Promipexole Ropinirole |
| Apomorphine | DA agonist |
| Dihydroxidine | DA agonist |
| bromocriptin | DA agonist |
| promipexole | DA agonist |
| ropinirole | DA agonist |
| DAR antagonist | spiperone ecopipam amisulpride chlopromazine haloperidol respiradol trifluroperazine |
| spiperone | DAR antagonist |
| ecopipam | DAR antagonist |
| amisulpride | DAR antagonist |
| chlopromazine | DAR antagonist |
| haloperidol | DAR antagonist |
| respiradol | DAR antagonist |
| trifluroperazine | DAR antagonist |
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