| Term | Definition |
|---|
| AML good/bad cytogenetics | good: t(15;17), bad: Monosomy 5,7 |
| ALL good/bad cytogenetics | good: hyperdiploidy (>50ch's). Bad: hypodiploidy, c-myc abnormalities: t(8;14) t(2,8) t(8;22), t(9;22) |
| LAP important for diagnosing | CML |
| tartrate resistant acid phosphatase (TRAP) for diagnosing | HCL |
| flow important for dx of | LYMPHOID PROCESSES: ALL, CLL/SLL, atypical lymphocytosis, HCL |
| cytogenetic/molecular assays important for dx | CML |
| PB of CML | neutrophilia w/ left shift, increased basophils, increased or nml platelets |
| BM of CML | hypercellular, decreased fat, increased M:E |
| cytichemistry of CML | decreased LAP |
| flow of CML | not helpful (unless in blast phase) |
| CML vs benign neutrophilia | LAP score, fat in marrow, whether there are increased basophils, appearance of karyotype |
| things that cause lymphocytosis | CLL, HCL, atypical lymphocytosis (benign) |
| CLL flow | mature B (19, 22, 23, light chain), CD5 |
| Dx of CLL | lymph>5000/ml, smudge cells, negative TRAP, mature B phenotype w/ 5 and 23 |
| appearance of lymphocytes in benign lymphocytosis | "kissing" the RBCs |
| flow of atypical lymphocytosis shows | predominance of T cells and polyclonal B cells, K and L. Atypical lymphocytes, negative TRAP |
| Hairy cell leukemia: presentation and labs | MALE w/ splenomegaly, pancytopenia, dramatic response to therapy. Monoclonal B cells positive for TRAP. |
| Flow of HCL | mature B cells (19, 22) + 11c, 25, and 103 |
| Effects of abnormal plasma cells in marrow | lytic dz, hypercalcemia, nerve root compression, anemia, hypogammaglobulinemia |
| monoclonal immunoglobulin is usually... | IgG (60%), IgA, light chains |
| effects of high levels of Ig from plasma cells | rouleaux, renal dz, amyloid, hyperviscosity, cryoglobulins, coag abnormalities |
| renal dysfunction in myelodyscrasia caused by | Bence jones protein (free light chains in urine), light-chain cast nephropathy, amyloid |
| dx of amyloid | positive w/ congo red |
| dz that gives lymphoplasmacytic morphology | Waldenstroms |
| Waldenstrom phenotype | mature B. BM shows plasma cells + lymphocytes (no fat) |
| Waldenstrom's is low grade lymphoma often involving... | bone marrow and spleen |
| person presents w/ HA, blurred vision. Order... | think waldenstrom's. BM, SPEP, serum viscosity |
| person presents w/ renal, heart, neuro dz. order... | congo red (amyloid) |
| person presents with bone lesions, hypercalcemia, renal dysfunction, infection. order... | SPEP, IEF (MM) |
Combine with other sets
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