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5 Written questions

5 Matching questions

  1. Aspergillus
  2. Lifecycle of chylomicron
  3. Most common source of E coli bacteremia
  4. Double stranded DNA viruses associated with cancer
  5. Amphotericin B
  1. a Septate, branching at 45 degree angle
    -May have neutropenia
    -Can be found in sinuses, aspergillomas (fruity bodies in your lungs)
  2. b EBV- causing non-Hodgkin lymphoma or B cell lymphoma
    HHV-8- causing Kaposi sarcoma
  3. c severe fungal infection
  4. d Chylomicron particle shrinks:
    Chylomicron is synthesised by intestinal epithelial cells and are scaffolded on apoB-4 and are first drained into lymphatic tissue where they enter the thoracic duct, dump into blood and enter the bloodtsream where they are delivered to the capillary bed surrounding adipose tissue. Lipoprotein lipase breaks down the triglyceride being carried by the chylomicrons into glycerol and fatty acids. The glycerol is sent to the liver, while the fatty acids go to the adipose tissue.
    -The lipoprotein lipase is found on the capillary beds (endothelial tissue) around the adipose cells
  5. e Urinary tract

5 Multiple choice questions

  1. MOA: Vancomycin binds to D-alanyl-D-alanine termini in cell wall peptide precursors and prevents the formation of peptidoglycan.
    MOResistance: Involves a change in the peptide precursor structure that alters the vancomycin binding site from a
    D-alanyl-D-alamine --> D-alanine-D-lactate
    -Substitution of D lactate in the place of D alanine during peptidoglycan cell wall synthesis
  2. Colorectal cancer
  3. Treats: Serious infections (especially typhoid fever) but attacks a wide spectrum of bacteria and bacterial meningitis
    MOA: a bacteriostatic drug that stops bacterial growth by inhibiting protein synthesis at 50S; interferes w substrate binding
    MOResistance: Plasmid-mediated acetyltransferases that inactivate the drug
    Tox: Gray baby syndrome, aplastic anemia/bone marrow suppression, GI irritation, pancytopenia
  4. Found in macrophages
  5. Treats: TB
    MOA: inhibits enzyme synthesis for mycolic building blocks.
    SD: nausea, peripheral neuropathy, hepatotoxicity, liver dsfxn, seizures, fever, anorexia, nausea
    Antidote: Pyridoxine

5 True/False questions

  1. t1/2Used to test for fungi

          

  2. diptheriatumbling motility, facultative IC, unpasteurized milk/cheese; deli meats; vaginal transmission

          

  3. DNA virusesCoronaviruses - common cold and SARS

          

  4. Meds commonly associated with cutaneous photosensitivitysulfonamides, amiodarone, tetracyclines (Doxycycline

          

  5. Rheumatic feverAutoimmune reaction that occurs following reaction that occurs following untreated Strep A pharyngitis. Ag similarity between bacterial Ag and normal self Ag in the heart and CNS are believed to cause formation of anti-self Ab resulting in RF

          

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