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5 Written Questions

5 Matching Questions

  1. hyperpyrexia
  2. How do you treat serotonin syndrome?
  3. Nitrate drugs
  4. measles
  5. Legionella pneumophilia
  1. a rubeola; transmission: respiratory droplets; symptoms: hacking cough, sneezing, nasal discharge, eye redness, sensitivity to light, high fever CHARACTERISTIC RED RASH; Koplik spots: red patched with white grain-like center appears on gum line; vaccine: MMR
  2. b very high fever (105.8); can lead to permanent brain damage
  3. c NO--> ↑cGMP--> myosin dephosphorylation
    When Ca entry into the cell is ↑, the cell also releases its intracellular source. As such when there is an ↑cGMP, this blocks Ca entry and thus blocks Ca intracellular stores. By blocking this action, you get muscle dephosphorylation and thus muscle relaxation
  4. d Cyproheptadine
    -"Periactin," is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
  5. e -Propensity to cause disease in smokers consisting of very high fever, diarrhea, headache and confusion
    G-ve rod
    Tx: erythromycin
    Legionnaire's disease

5 Multiple Choice Questions

  1. severe fungal infection
  2. Chylomicron particle shrinks:
    Chylomicron is synthesised by intestinal epithelial cells and are scaffolded on apoB-4 and are first drained into lymphatic tissue where they enter the thoracic duct, dump into blood and enter the bloodtsream where they are delivered to the capillary bed surrounding adipose tissue. Lipoprotein lipase breaks down the triglyceride being carried by the chylomicrons into glycerol and fatty acids. The glycerol is sent to the liver, while the fatty acids go to the adipose tissue.
    -The lipoprotein lipase is found on the capillary beds (endothelial tissue) around the adipose cells
  3. (Vd*ln 2)/CL where Vd=volume of distribution, CL=clearance
  4. -Nitroimidazoles are around to clean up organisms that the big drug classes-penicillins, cephalosporins, etc miss. Worried about anerobes? Metro is there for you. Thinking about parasites in your pt w diarrhea? Try metro
    Treats: Antiprotozoal antibiotic: drug of choice in extraluminal amebiasis and trichomoniasis; effective against bacterial anaerobes, including B fragilis and in antibiotic-induced colitis resulting from C difficile.
    Tox: Peripheral neuropathy, GI distress, ethanol intolerance, mutagenic potential.
  5. Confusion, restlessness, HTN, tachycardia, clonus, hyperreflexia, shivering, diaphoresis

5 True/False Questions

  1. Aspergillusmonomorphic mold, with hyphae that branch at angles <45 degrees. especially affects immunocompromised and those with chronic granulomatous disease

          

  2. RifampinShould not be used in children <12 yo as it will cause Reye syndrome

          

  3. Vancomycin resistanceMOA: Vancomycin binds to D-alanyl-D-alanine termini in cell wall peptide precursors and prevents the formation of peptidoglycan.
    MOResistance: Involves a change in the peptide precursor structure that alters the vancomycin binding site from a
    D-alanyl-D-alamine --> D-alanine-D-lactate
    -Substitution of D lactate in the place of D alanine during peptidoglycan cell wall synthesis

          

  4. FlumazenilBenzo antagonist;
    This drug is used for benzodiazepine overdose but can cause withdrawal seizures in alcoholics or chronic benzo users

          

  5. Heat Labile toxintargets cell wall.

          

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