antibiotics lec 1 key pts

6 Written Questions

1. displacement of bilirubin from serum albumin
2. latex agglutination
3. shift to the left
4. Immature neutrophils
5. culture
6. hematologic toxicities d/t prolonged use

6 Multiple Choice Questions

1. drugs that can cause FEVER
   1. achieve synergistic activity against infecting organism, examples are in treating what
   2. with all antibiotics this is possible
   3. Can develop kernicterus when given sulfonamides as a result of
   4. β-lactam antibiotics, anticonvulsants, allopurinol, hydralazine, nitrofurantoin, sulfonamides, phenothiazines, and methyldopa
2. phenytoin
   1. isoniazid can inhibit the metabolism of _____ leading to toxicity
   2. Mature neutrophils referred to as segs because of their
   3. with all antibiotics this is possible
   4. Absorption
      Distribution
      Metabolism
      Excretion
3. Pharmacodynamics
   1. Absorption
      Distribution
      Metabolism
      Excretion
   2. Mature neutrophils referred to as segs because of their
   3. with all antibiotics this is possible
   4. Time above MIC
      AUC/MIC ratio
      Peak:MIC ratio
4. MBC
   1. Isolation of the etiologic agent by ________ is the most definitive method available for the diagnosis of infection
   2. the lowest concentration of drug that kills 99.9% of the total initially viable cells (a 3 log10 CFU/ml or greater reduction in the starting inoculum)
   3. The change in ratio of mature to immature cells is referred to
   4. Lowest antimicrobial concentration that prevents visible growth of an organism after 24 hours of incubation in a specified growth medium
      Used to determine in vitro antibacterial activity
5. IE-> causitive agent inhibited by pcn but killed rapidly by addition of aminoglycoside to pcn
   1. Can develop kernicterus when given sulfonamides as a result of
   2. achieve synergistic activity against infecting organism, examples are in treating what
   3. Prevent emergence of resistance
      Particularly important in the treatment of
   4. The change in ratio of mature to immature cells is referred to
6. segmented nucleus
   1. Can develop kernicterus when given sulfonamides as a result of
   2. Time above MIC
      AUC/MIC ratio
      Peak:MIC ratio
   3. with all antibiotics this is possible
   4. Mature neutrophils referred to as segs because of their

5 True/False Questions

1. Absorption
   Distribution
   Metabolism
   Excretion → pharmacokinetics (how the drug moves through the body)

   True        False

2. Lowest antimicrobial concentration that prevents visible growth of an organism after 24 hours of incubation in a specified growth medium
   Used to determine in vitro antibacterial activity → MIC

   True        False

3. with all antibiotics this is possible → Immature neutrophils

   True        False

4. occurs frequently with acute viral infections such as Epstein-Barr virus (mononucleosis) infection or CMV (cytomegalovirus) infection → lymphocytosis

   True        False

5. Prevent emergence of resistance
   Particularly important in the treatment of → tuberculosis

   True        False