Path - Chp 24 - 02

5 Written Questions

1. tumor, trauma, surgery, apoplexy, Sheenhan, Rathke cleft cyst, Empty sella, genetic, inflamm
2. binds hormone-receptor complex in nucleus
3. inhibit thryoid gland function, causing goiter (thyroid enlargement)
4. produce calcitonin
5. children; dystrophic calcification, spongy reticulum, palisading, (cysts - machine oil)

5 Matching Questions

1. TSH pathway (thyroid)
2. papillary craniopharyngioma
3. empty sella syndrome
4. Rathke cleft cyst
5. thyroid hormone receptor (TR)

1. a primary - defect causes herniation
   secondary - removal/necrosis causes loss of function
2. b binds thryoid hormone
3. c accumulates proteinaceous fluid
4. d adults; lack keratin, calcification, cyts
5. e Gs protein, ↑cAMP, protein kinase

5 Multiple Choice Questions

1. thyrotoxicosis, elderly
   1. apathetic hyperthyroidism
   2. TSH pathway (thyroid)
   3. Rathke cleft cyst
   4. hyperthyroidism (cause)
2. postpartum necrosis of anterior pituitary due to obstetric hemorrhage/shock
   1. empty sella syndrome
   2. Sheenhan syndrome
   3. thryoid storm
   4. SIADH
3. hypermetabolic state, ↑sympath, BMR
   cardiac, NM, ocular, GI, skeletal
   1. hypopituitarism (mechanisms)
   2. thyrotoxicosis
   3. hyperthyroidism (cause)
   4. hyperthyroidism (clinical)
4. cystic, near optic chiasm, adamantinomatous or papillary
   1. thryoid storm
   2. hyperthyroidism (cause)
   3. papillary craniopharyngioma
   4. craniopharyngiomas (morph)
5. glioma, craniopharyngioma
   1. apathetic hyperthyroidism
   2. hypopituitarism (mechanisms)
   3. thyroglobulin (converted to)
   4. hypothalamic suprasellar tumor

5 True/False Questions

1. central diabetes insipidus → ADH deficiency causing excessive urination due to inability of kidney to resorb water

   True        False

2. thyrotoxicosis → abrupt onset of severe hyperthyroidism, febrile/tachycardic

   True        False

3. thyroglobulin (converted to) → thryoxine - T4, triiodothyronine - T3

   True        False

4. nephrogenic diabetes insipidus → ADH deficiency

   True        False

5. proplythiouracil → inhibit thryoid gland function, causing goiter (thyroid enlargement)

   True        False