USMLE World Review Antibodies

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antimicrosomal

hashimotos thyroiditis

antithyroglobulin

hashimoto's thyroiditis

anti-DNA topoisomerase I antibody (anti-Scl-70)

Diffuse scleroderm - more aggressive

anti-centromere antibody

CREST - more benign

antinuclear antibodies

SLE - nontspecific
sjogren's, scleroderma, polymyositis, dermatomyosystis, arthritis, juvenile arthritis, mixed connective tissue disease

anti-dsDNA, anti-smith

specific for SLE

antihistone

drug-induced lupus

anti-igG

Rheumatoid factor
RA

anti-mitochondrial

primary biliary cirrhosis

anti-gliadin, anti-endomysial, antitransglutaminase

celiac

anti-basement membrane

goodpasture's

anti-desmoglein

pemphigus vulgaris

anti-jo-1

polymyositis, dermatomyositis

anti-SS-A (anti-ro)

sjogren's syndrome
ribonucleoprotein

anti-SS-B (anti-La)

sjogren's
ribonucleoprotein

anti-U1 RNP (ribonucleoprotein)

mixed connective tissue disease

anti-smooth muscle

autoimmune hepatitis

anti-glutamate decarboxylase

type 1 diabetes mellitus

c-ANCA - central anti-neutrophilic antibody

wegener's granulomatosis (proteinase-3)

p-ANCA - peripheral

churg-strauss syndrome
enzyme myeloperoxidase - microscopic polyangiitis
Ulcerative colitis
p-ANCA

thyroid-stimulating immunoglobulin

TSI stimulates thyroid production in Grave's

urine metanephrine

most specific for pheocromocytoma
24 hrs
also catecholamine

gamma glutamyl transpeptidase

cholestatic disease of the liver
alkaline phosphatase will be high also (same as bone dysfunction)

S-100 immunoreactivity

neural crest cell tumor
melanoma, schwannoma

CA-125

malignant ovarian epithelial cells in serous, endometriod, and clear cell carcinomas of the ovary

anti-cyclic citrullinated protein

rhematoid - more specific than RF

anti-bodies U1ribo-nucleo-protein

mixed connective tissue disease

anti-saccharomyces cerevisiae (ASCA)

Crohn's disease

CEA tumor marker

colorectal cancer
pancreatic adenocarcinoma (CA-19-9 as well)

5-HIAA in urine

Serotonin syndrome

prostatic acid phosphatase

prostate carcinoma

alpha-fetoprotein

hepatocellular carcinomas, nonseminomatous germ cells (testis)

beta-hCG

hydatidiform moles
choriocarcinomas
gestational trophoblastic tumors

alkaline phosphatase

metastases to bone, obstructive biliary disease
paget's disease of bone

bombesin

neuroblastoma, lung, gastric cancer

TRAP

tartrate-resistant acid phosphatase
hairy cell leukemia

CA-19-9

pancreatic adenocarcinoma

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