All malignant bone-forming tumors are called this
Axial skeleton (especially the spine)
Osteosarcomas that are closest to this are the most deadly
This osteosarcoma is centrally located inside the bone
Accounts for 70% of malignant bone-forming tumors
70% (72% by book)
Osteosarcomas-Central account for what percent of all malignant bone-forming tumors
Central Sclerotic Osteosarcoma
What is the most common osteosarcoma?
Central Sclerotic Osteosarcomas account for what percent of all osteosarcomas?
Osteosarcoma-Central Lytic and Osteosarcoma-Central Sclerotic
What are the two subtypes of Osteosarcomas-Central?
This is a bone generating osteosarcoma (produces bone malignantly)
75% of Osteosarcoma-Central tumors
Likely involves osteoblasts
Only malignant bone tumor that PRODUCES bone
Osteosarcoma-Central Blastic account for what percent of all Osteosarcoma-Central tumors?
This Osteosarcoma-Central tumor is a bone destroyer
Accounts for 25% of all Osteosarcomas-Central tumorsc
50% Osteosarcoma-Central Sclerotic
25% Osteosarcoma-Central Lytic
25% Osteosarcoma-Central Mixed (Sclerotic and Lytic)
Alternative percentages for Osteosarcoma-Central tumors
Second most common primary malignant bone tumor
1,500 cases in US at any one time (not all that common in the broad scheme)
20% of all malignant bone tumors
Osteosarcoma-Central frequency of occurrence
What percent of all malignant bone tumors are Osteosarcoma-Central type?
2:1 male predominance
Sex ratio for Osteosarcomas is what?
They have been found to be taller than their peers in the corresponding age group
Don't know why
What is one unexplained trait of those with Osteosarcoma-Cenral?
Like bone is on fire at one end (?)
Tend to be aggressive and expansile
Can get through cortex with substantial soft tissue masses surrounding the host bone (common)
Large periosteal responses (spiculation and Codman's Triangles)
PRODUCES BONE (only malignant tumor to do this)
Radiographic appearance of Osteosarcoma-Central Sclerotic
Large PO responses...
Spiculation and Codman's Triangles
What are the periosteal responses to Osteosarcoma-Central Sclerotic?
Moth-eaten and/or permeative pattern of lysis
Also see periosteal reactions: spiculation and Codman's T's
Lest distinct than sclerotic, so there are more differentials
Radiographic characteristics of Osteosarcoma-Central Lytics
Spiculation and Codman's T's (Like sclerotic, but less so)
Less distinct than sclerotic, so there are more differentials
Periosteal responses with Osteosarcoma-Central Lytic
What is the only malignant tumor to produce bone?
Like femurs a lot, especially distal femoral metaphysis
Most common joints are knee and shoulder (58% knee and 15% at humerus)
Proximal tibia and fibula, humerus
Less common: Iliac crest
Where are Osteosarcoma-Central tumors found?
Percent of Osteosarcoma-Central joint tumors found around knee?
Percent of Osteosarcoma-Central joint tumors found at the humerus?
What is most common area to find an Osteosarcoma-Central?
What part of it?
Proximal tibia and fibula
Is an Osteosarcoma-Central is found in the tibia or fibula, what area is it likely to be in?
Most under 30
Peak is teen years
Age for Osteosarcoma-Central
Teen with insidious onset of increasing localized pain just about the knee
Deep bone pain; achy
Classic presentation of Osteosarcoma-Central
Painful swelling at site of lesion is the presenting complaint in 85% of patients
Are Osteosarcoma-Central tumors painful?
For what percent of patients is painful swelling at site of lesion the presenting complaint for patients with Osteosarcoma-Central tumors?
To the lungs
Osteosarcoma-Central tends to metastasize where?
Often goes to lungs
Do Osteosarcoma-Central tumors often metastasize to other parts of the skeleton?
Leg may be amputated at the hip and treated aggressively
If Osteosarcoma-Central is contained, what is treatment?
Doesn't go to spine
As things get closer to axial skeleton they tend to be harder to treat
What is good thing about Osteosarcoma-Central?
Around the bone
Parosteal Osteosarcomas tumors occur where?
Centrally located inside the bone
Osteosarcomas-Central occur where?
Parosteal Osteosarcomas accout for what percent of all Osteosarcomas?
Grow in somewhat of an up/down direction
Have daughter masses in soft tissue
Growth characteristics of Parosteal Osteosarcomas
Do Parosteal Osteosarcomas invade the bone/cortex?
Can see attachment point, with growth up and down with a thin lucency
White fuzzy mass/mushroom cap
Radiographic characteristic of Parosteal Osteosarcoma
This is a variant of Osteosarcoma occurring between the periosteum and the cortex
Periosteal Osteosarcomas account for what percent of Osteosarcomas?
Which Osteosarcoma has the best prognosis?
Periosteal Osteosarcoma is more common in what age group?
Don't attach to bone or soft tissue
Grows on top of cortex and not into bone
Sandwiched between cortex and periosteum
What is the makeup of Periosteal Osteosarcomas?
Grows on top of cortex (not into bone)
Sandwiched between cortex and periosteum
Is actually subperiosteal
Location of Periosteal Osteosarcomas
About what percent of Periosteal Osteosarcomas are subperiosteal?
Could be post-traums calcification of soft tissue that happens in big muscles
Differentials for Periosteal Osteosarcomas
Fuzzy mass with non-homogenous internal appearance
May see Codman's Triangles from slow rising periosteum in ends of tumors
Could see spicules too
Radiographic appearance of Periosteal Osteosarcoma
Kids under age 10
Osteosarcomatosis is usually found in who?
Usually starts in multiple places at the same time
Growth pattern of Osteosarcomatosis
Osteosarcomatosis accounts for what percent of Osteosarcomas?
Extraosseous Osteosarcomas account for what percent of Osteosarcomas?
2-3% of Osteosarcomas
This is a tumor completely contained in the soft tissue and doesn't seem to have an osseous origin
Occurrence of Paget's Disease
What percent of Osteosarcomas come from Paget's Disease?
4% of all Osteosarcomas
This is a malignant degeneration of Paget's Disease
Accounts for what percent of Osteosarcomas?
Osteosarcoma of the jaw
This is very uncommon
Occurs only in the mandible
Only in the mandible
Where do Osteosarcomas of the jaw occur?
Less than 1%
Malignant Degeneration from something pre-exhisting accounts for what percent of all Osteosarcomas?
Benign (uncommon) or malignant
Malignant Degeneration from Something Pre-exhisting tumors can come from what type of tumor?
Associated with Malignant Degeneration from Something Pre-exhisting
These are tumors in the vascular system
Extremely malignant tumor of bone
Rapid progression and short survival time
Describe Teleangiectatic Osteosarcoma
Less than 1%
Radiation-Induced Osteosarcoma account for what percent of all Osteosarcomas?
If bone is in the way, post-radiation Osteosarcoma may develop
How many rads delivered to a controlled area to treat cancer?