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Death from a TCA is usually due to what?

V-fib and/or cardiogenic shock (inhibits cardiac fast NA channels)

cardiomyopathy associated with -rubicins?

dilated cardiomyopathy

Fexofenadine is what class of drug?

second generation antihistamine

Hydroyzine is what class of drug?

first generation antihistamine

promethazine is what class of drug?

first generation antihistamine

chlorpheniramine is what class of drug?

first generation antihistamine

first generation antihistamines?

hydroxyzine, promethazine, chlorpheniramine, diphenhydramine

warfarin is metabolized how?

P450

medication for atrial fibrillation that can cause heart block and diarrhea?

digoxin

medication for atrail fibrillation that can cause heart block and constipation?

Ca channel blocker (verapamil, -dipines, diltiazem)

dobutamine is of what drug class?

B-agonist prominently (some B2 and a1)

vitamin that will increase levodopa metabolism?

Vit B6

class of drug to treat dry mouth, flushed skin, dilated pupils that are non-reactive to light after being outdoors?

AChE inhibitor

long acting benzos?

CCDF (The bad grades for older people) chlordiazepoxide, clorazepate, diazepam, flurazepam

how do -afils affect vascular smooth muscle?

inhibit PDE blocking metabolism of cGMP (NO causes an increase in cGMP - reason why nitrates with PDE inhibitors cause problems)

K conductance is what phase of the ventricular action potential?

3

what antiarrhythmic modulates phase 0 of the ventricular action potential?

Class I (Na influx)

what antiarrhythmic modulates phase 1 of the ventricular action potential?

none (Na influx slows; K permeability increases)

what antiarrhythmic modulates phase 2 of the ventricular action potential?

Class IV (Ca influx and minimal K efflux- so Class 3 has minor influence)

What antiarrhythmic modulates phase 3 of the venricular action potential?

Class III (K efflux)

What antiarrhythmic modulates phase 4 of the ventricular action potential?

None - balanced ion flow

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