Ch 44 Outline Neurologic Disorders 4
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14 terms
Terms | Definitions |
|---|---|
 Myasthenia Gravis Incidence greater in men | Manifestations manifest generally >50, Chronic, Autoimmune, Neuromuscular disorder, Periods of remission/exacerbation |
| Myasthenia Gravis Pathophysiology | Antibodies destroy or block neuromuscular junction receptor sites, Decrease number of acetylcholine receptors, Results in decreased ability of muscle to contract |
| Myasthenia Gravis Manifestations | Diplopia or ptosis, Difficulty chewing food, Dysarthria, Dysphagia, Weak facial and speech muscles, Spreads as disease progresses |
| Myasthenia Gravis Complications Myasthenic crisis | Sudden exacerbation of motor weakness caused by undermedication |
| Myasthenia Gravis Diagnosis | Anticholinesterase test, Nerve stimulation studies, Analysis of anti-acetylcholine receptor antibodies |
| Myasthenia Gravis Meds | Anticholinesterases, Glucocorticoids |
| Myasthenia Gravis cholinergic crisis | result of overdosage with the cholinergic medications; severe muscle weakness, vertigo, and respiratory distress are signs |
| Anticholinesterases | allow acetycholine to gather at receptor sites which promotes muscle contraction |
| Pyridostigmine | Mestinon; most common used acetycholinesterase inhibitor |
| Glucocorticoids | improves muscle strength by immunosuppression |
| Thymectomy For patients under 60 Two surgical approaches | Transcervical approach, Transternal approach |
| Rhizotomy | Surgical severing of a nerve root |
| Percutaneous rhizotomy | Partially destroys trigeminal nerve |
| Plasmapheresis | Procedure used to separate blood cells from plasma, Used for treatment of MG and GB |
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