| Term | Definition |
|---|
| Structure: | Nuclear envelope and pores, Nuclear lamina with perinuclear heterochromatin, Nuclear matrix, Nucleolus; |
| Two distinct routes of protein insertion: | Insertion of membrane and perinuclear proteins from nuclear bound ribosomes same as ER, or Insertion of soluble proteins from cytoplasmic ribosomes via pores, which is Distinct from other organelles since does not require protein denaturation and refolding; |
| nuclear lamina: | bind the inner membrane and perinuclear heterochromatin; |
| Hutchinson-Gliford progeria syndrome: | mutations in lamin genes, single nuc. change in lamin A, accelerated aging, cryptic RNA splice site so truncated protein, altered nuclei; |
| nuclear matrix: | Internal nuclear structure of protein "fibrillar structures", Contacts lamina, pores, and chromatin, anchors for chromatin loops, organize subnuclear structures containing transcription and splicing factors, may act as tracts for RNA movement to pores; |
| Nucleolus function: | synthesize rRNA and assemble ribosomes, also may store transcription factors |
| Mutations in nucleolus linked to: | cancers, ND diseases, developmental disorders; |
| Small nucleoli fuse to form large one when: | in resting or late G1 interphase; |
Combine with other sets
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