Cards II Pharm

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drugs that increase cGMP

hydralazine, nitroprusside, nitroglycerin

aphrodisiac and erection enhancer

nitroglycerin, isosorbide dinitrate

K+ channel opener
-hyperpolarizes and relaxes vascular smooth muscle-

diazoxide

reduces insulin release
-can cause hyperglycemia-

diazoxide

D1 receptor agonist
-relaxes renal vascular smooth muscle-

fenoldopam

can cause cyanide toxicity

nitroprusside

release of nitric oxide

nitroprusside, nitrates

decreases preload

nitroglycerin, isosorbide dinitrate

blocks voltage-dependent L-type calcium channels
of cardiac and smooth muscle

calcium channel blockers

reduces muscle contractility

calcium channel blockers

what type of calcium channels do calcium channel blockers block?

L-type (voltage-dependent)

reduces afterload

hydralazine

effect of calcium channel blockers on vascular smooth muscle
by drug

nifedipine > diltiazem > verapamil

effect of calcium channel blockers on heart
by drug

verapamil > diltiazem > nifedipine

calcium channel blocker not used to tx arrhythmias

nifedipine

causes Monday Disease

nitrates

freq given with beta blocker to prevent reflex tachycardia

hydralazine

causes reflex tachycardia

hydralazine, nitroglycerin, isosorbide dinitrate

causes lupus-like syndrome

hydralazine

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