| Term | Definition |
|---|
| Co-translational protein targeting | proteins inserted into ER membrane while being translated by the ribosome |
| Post-translational protein targeting | proteins which have been translated by FREE ribosomes in the cytosol and have a targeting sequence to go to the mitochondria, peroxisome, or nucleus |
| examples of co-translational proteins | secretory proteins, membrane proteins, Golgi, lysozymes |
| Endoplasmic Reticulum | labyrinth bound compartment which synthesizes lipids, membrane bound proteins, and secretory proteins |
| Smooth ER | have no ribosomes |
| Lumen | an open space or cavity of an organ, as of a blood vessel or an intestine |
| Scramblase | a phospholipid translocator that takes lipid molecules from the cytosolic half and "transfers" the lipid molecules to the ER lumen so their is the same amount of lipids. only found in smooth ER |
| Flippase | Flips phosphatidylserine and phosphatidylethanolamine from the extracellular to the cytosolic leaflet |
| cytochrome p450 | protein in SMOOTH ER involved in detoxification rxns (when something like phenobarbitol is taken excessively) |
| Smooth ER is found | in liver cells (need membrane space to detoxify toxins like phenobarbitol) and steroid secreting cells |
| SRP | signal recognitions particle; when bound to mRNA, translation is stopped, receptor comes and translation begins again |
| Glutathione | disulfide bonds will not form in this type of reducing atmosphere in the cytoplasm |
| cystic fibrosis | common fatal gentic disease in which a protein fails to fold properly, resulting in a Cl imbalance in the lumens of a duct |
Combine with other sets
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