Central obesity and insulin resistance
Key risk factors for metabolic syndrome
Excess blood clotting and low levels of systemic inflammation
Metabolic syndrome can cause what two things to happen in the body?
M: > 40, W: >35
Waist circumference in men and women that is associated with metabolic syndrome
Risk of developing HTN increases for weight gain of ? after turning 18 years old
Classification of obesity that is known to be particularly dangerous; associated with fat mass becoming capable of hormone secretion
May not always correspond to excess fat/visceral fat
Major limitation of BMI
When is WC most helpful?
Best way of measuring visceral obesity
Energy expended at rest under condition of thermal neutrality
REE measured soon after awakening in the morning, at least 12 hours after the last meal
Hormone responsible for feeling hunger
Hormone responsible for feedback that leads to appetite suppression; becomes resistant as fat stores develop
Fat type that is vascularized and is actually thought to be protective
Protective adipokine that is downregulated as a result of adverse cardiometabolic effects
Wt loss percentage that has shown to have health benefits in obese patients
This receptor has been shown to play a key role in thermogenesis and when stimulated activates lipolysis in fat cells
>27 + comorbidities, >30
BMI cutoffs associated with initiating pharmacotherapy
>35 + comorbidities, >=40
BMI cutoffs for surgical intervention
Diet that seems to have equivocal weight loss and is capable for being maintained for longest period of time
Caloric intake associated with low calorie diet
Exercise that is more likely to burn/reduce calories
Exercise that is more closely linked to loss of visceral fat
Fatty/oily stool, fecal incontinence, increase in defecation
General SE of orlistat, especially in pts that don't change their diet
Serious SE of orlistat
Mg dosage of orlistat
Improvement in lipids, A1c, and can be used in weight maintenance
Benefits of orlistat in addition to short term weight loss
Diethlypropion, phentermine, benzphetamine, phendimetrazine
4 sympathomimetic drugs used in tx of weight loss
Time period which sympathomimetics are approved for treatment due to scheduling and addictive properties
CI for sympathomimetics
Bupropion, exenitide, pramlintide, metformin, topiramate
Drugs that aren't indicated for weight loss, but may cause beneficial weight loss as a SE and can also tx other conditions at the same time
Insulin, sulfonylureas, phenothiazines, antidepressants, lithium, antipsychotics, antiepileptics, glucocorticoids, progestins, thiazolidinediones
Drugs that are known to cause weight gain
Drug that is seeking approval that is being studied for possibility of birth defects
Leptin, neuropeptide Y
Centrally acting neuropeptides
Tablets and capsules; extended release
Drug formulations that should be avoided post bariatric surgery
OTS meds taken by pts should be free of this post bariatric surgery
Vitamin that should definitely be recommended for pts that are post bariatric surgery
Time between orlistat and levothyroxine administration?
Time between orlistat and cyclosporine administration?
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