Ch 18 Urinary System

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DrDavila Plus on April 25, 2012

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BIO104: Human Anatomy & Physiology II

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Dr Davila

Medical Careers Institute, ECPI University

Human Anatomy & Physiology II

BIO 104

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BIO104 Day

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Ch 18 Urinary System

3 urinary system functions
1. excretion
2. elimination
3. homeostatic regulation
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3 urinary system functions 1. excretion
2. elimination
3. homeostatic regulation
excretion removal of waste from blood
elimination discharge of waste products
homeostatic regulation maintain blood volume (and thus, blood pressure), blood pH, and conserve nutrients
kidney pair of retroperitoneal bean-shaped organs that filter water and waste materials from the blood, producing urine
retroperitoneal posterior to the peritoneum
urinary tract organs that eliminate urine; include ureters, urinary bladder, and urethra
ureters tubes that propel urine via peristalsis from kidneys to bladder
urinary bladder hollow, muscular sac that stores urine until elimination; may hold 1L of urine
urethra conducts urine out of the body; in males also transports semen
urination process of eliminating urine; aka micturition or voiding
micturition urination
renal pelvis funnel-shaped reservoir that collects urine and passes it to the ureter
renal cortex outer layer of the kidney containing the glomeruli and the convoluted tubules
renal medulla inner tissue layer of the kidney; contains loops of Henle and collecting tubules
renal pyramid conical wedges that makes up most of the renal medulla
renal colums bands of cortex tissue that separate the pyramids
nephron microscopic tubular structures that filter blood and produce urine; functional unit of the kidney
parts of a nephron renal corpuscle →
proximal convoluted tubule →
nephron loop (aka, loop of Henle) →
distal convoluted tubule →
collecting duct
nephron blood supply afferent arteriole
GLOMERULUS
efferent arteriole
peritubular capillaries
vasa recta
renal tubule includes proximal convoluted tubule, nephron loop (aka, loop of Henle), distal convoluted tubule, and collecting duct;
PCT→loop→DCT→duct
renal corpuscle Bowman's capsule and glomerulus at the start of a nephron; "little body in kidney"; where filtrate is formed
filtrate fluid from blood squirt through glomeruli pores into the Bowman's capsule; blood serum in nephrons
glomerulus spherical knot of intertwining capillaries; blood is filtered through pores in glomerulus
Bowman's capsule cup-shaped structure of nephron, which encloses the glomerulus; filtration occurs inside here
proximal convoluted tubule first section of the renal tubule that the blood flows through; reabsorption of water, ions, and all organic nutrients
nephron loop second part of tubule that dips into the medulla; reabsorbs water and salt (sodium and chloride ions); aka, loop of Henle
distal convoluted tubule third part of tubule; selectively reabsorbs (water, sodium, calcium) and secretes wastes here, only if needed
collecting ducts last part of tubule, which receives filtrate from many nephrons; selectively reabsorbs water & ions (may secrete ions); delivers urine to calyxes and then renal pelvis
purpose of urine production maintain homeostasis
excrete solutes (wastes and excess ions)
regulate blood pressure
metabolic waste urea
uric acid
creatinine
3 urine formation processes filtration
reabsorption
secretion
filtration process whereby fluids are forced through a filter;
fluid is serum, force is blood pressure, filter is glomerular pores
reabsorption process in nephron that saves useful substances (water, glucose, amino acids) from filtrate back into blood
secretion process whereby nephron actively pumps wastes into filtrate
glomerular filtration rate speed at which gomeruli produce filtrate; affected by blood pressure and volume
urinalysis analysis of a urine sample; important diagnostic tool
renin angiotensin system hormone pathway that increases thirst and raises blood pressure if blood volume falls (often due to dehydration), detected as decreased blood flow to the kidneys; aka RAS or renin-angiotensin-aldosterone system (RAAS)
aldosterone hormone that increases sodium reabsorption, thereby increasing water reabosrption; (recall in osmosis "water follows stuff/salt"); "aldosterone saves sodium" & kicks out K+ [potassium]
antidiuretic hormone signal in blood (from posterior pituitary) that increases water reabsorption from filtrate in nephrons, thereby decreasing urine production;
atrial natriuretic peptide hormone secreted by atria (upon increased blood flow/pressure) which increases sodium excretion; (recall in osmosis "water follows stuff/salt")
external urethral sphincter circular band of voluntary skeletal muscle on pelvic floor; voluntarily relaxes to allow micturition
internal urethral sphincter involuntary smooth muscle at bladder-urethra junction that contracts to open
fluid compartments Intracellular fluid (ICF): approx. 60% of body's water
Extracellular fluid (ECF): approx 40% of body's water
water flows freely between 2 compartments
water balance water intake equals loss (from feces, urine, and insensensible perspiration); require about 2.5 L daily; 1L from food, 1.2L from drinking, 0.3L from aerobic metabolism
fluid shift rapid water movements between ECF and ICF due to osmosis (ie, more water in one compartment than another)
hypertonic ECF pulls water out of cells and into ECF (more "stuff" than water in ECF); cells shrivel
hypotonic ECF water pushes into cells and out of ECF (more water than "stuff" in ECF); cells swell
electrolyte balance usually referring to the balance of sodium (Na+) & potassium (K+) ions
acidosis processes that result in abnormally low pH ; eg. metabolic and respiratory acidosis
acidemia abnormally low plasma pH <7.35
alkalosis processes that result in abnormally high pH; eg. CO2 levels too low
alkalemia abnormally high plasma pH >7.45
buffer resists changes in pH temporarily ; (eg. proteins, carbonic acid, and phosphates all help resist pH changes temporarily)
renal compensation kidney varies acid (H+) secretion and bicarbonate reabsorption depending on pH of ECF; eg. kidney removes excess acid from plasma
respiratory compensation changes in ventilation change pH by increasing or decreasing CO2 levels; eg, lungs exhale plasma acid as CO2

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