# Oxygen Transport

### 54 terms by melissajnkns

#### Study  only

Flashcards Flashcards

Scatter Scatter

Scatter Scatter

## Create a new folder

### What is the equation for oxygen delivery to tissues?

Cardiac Output x Oxygen Content
DO2 = CO x CaO2

### What are the two main compartments that get oxygen out to tissues?

Hemoglobin and Plasma

1.34 x Hb x SaO2

.003 x PaO2

### Plasma or Dissolved Compartment

O2 physically dissolved into blood, in capillary area.
Henry's Law
PO2

### Hemoglobin or Combined Compartment

O2 chemically attaches to hemoglobin, can load up in lungs and unload. 98% of O2 carried this way.
Each gram of Hb can carry 1.34 ml of O2
Normal = 15 grams% per 100 ml of blood.
HCT / 3 =Hb.

### As PO2 goes up your PaO2 goes up T or F

True, there is a direct relationship

### For every 100 ml of blood 5 vol% are extracted T or F

True, this is the A-V difference

15 vol%
Right Heart

20 vol%
Left Heart

250 ml/min

200 ml/min

5 LPM

75%
40 Torr

97%
90 Torr

2-5%

### What is Venous Ad mixture?

Oxygenated and NonOxygenated blood mixed

### Shunt

Perfusion without Ventilation

### What is the Transit time?

Less than 1 second
It is how long the RBC is in contact with the area where gas exchange takes place.

280 Million

### How many molecules can the Hb hold? Atoms?

4 molecules or 8 atoms

150

### Carbon Monoxide has what affinity ?

250x more than oxygen

### Define Reduced Hb

Uncombined or deoxygenated Hb
Hb not bound with O2

### Oxyhemoglobin Dissociation Curve

Relationship between PO2 and SO2

### PO2 of 60

Is SaO2 of 90
if curve is normal

### P50

What PO2 does it take to saturate hemoglobin to 50%
pH has a big effect on P50
When normal P50 is 27 Torr

### Explain the steep part of the curve

How a small change in PO2 can cause a big change in the SaO2

### Pulse Oximeter

Tells how much your hemoglobin is saturated

### Shift to Right

P50 goes up. Makes it easier to give up O2, at tissue level

### Shift to Left

P50 goes down. Holds onto O2 tighter. Loads up easier at capillary level.

### Left Shift Causes

High- pH Low-PCO2, Low-Temp, Low-DPG,
HbF-(Fetal)
COHb

### Right Shift Causes

Low-pH High-PCO2, High Temp, High-DPG

### DPG

Contained inside RBC
Hb affinity for O2 decreases as DPG increases

### Factor affecting CaO2-Anemia

Only 1/2 as much ability to do O2 transport by reducing amount of Hb to carry O2

### Factor affecting CaO2-Polycythemia

Opposite of anemia, Increases Hb unless a result of Chronic Lung Disease

### Factor affecting CaO2-Cyanide

Blocks ability of cells to uptake O2 at mitochondrial level
A-V difference becomes zero

### Factor affecting CaO2-Altitude

Increases Hb over time, but SaO2 and PaO2 stay low.
Increase altitude =decrease PIO2
Short term= SaO2 and PaO2 decreases

### Factor affecting CaO2-Hyperbarics

Only slightly affects SaO2 but affects plasma significantly

### Factor affecting CaO2- Carbon Monoxide

Hb affect cant do O2 transport because its bound up with Carbon Monoxide PO2 not reliable anymore

### If you keep the numbers the same and you reduce Co what happens?

Only half as much O2 is delivered, but the content is the same. When CO decreases your DO2 changes.

### Factors that decrease the SvO2

Decreased CO, Periods of increased O2 consumption
Exercise, Seizures, Shivers, Hyperthermia

Hypoxic Hypoxia
Anemic
Circulatory
Histotoxic

### Hypoxic Hypoxia

Low Alveolar PO2, Diffusion Impairment, V/Q Mismatch
Fix=Increase FIO2

### Define Hypoxia

Low O2 at the cellular level

### Define Hypoxemia

Low O2 in the blood

V/Q Mismatch

### Anemic Hypoxia

Low O2 at cellular level because of anemia
Blood carrier problem, Low Hb, Inability of Hb to carry O2
Ex. Carbon monoxide poisoning

### How to treat Carbon Monoxide Poisoning

1st-get out of area to fresh air
2nd-Use non-rebreather to give highest FIO2 possible
3rd-Evaluate need for Hyperbaric chamber

### Circulatory Hypoxia (Stagnet)

Arterial Venous Shunting-instead of going to tissues arterial blood goes back to venous blood circulation
Blood doesnt circulate well
No adequate perfusion to the core during CPR

### Histotoxic Hypoxia

Classic Example-Cyanide poisoning
Tissues cant uptake O2
Cyanide doesnt allow the cells to utilize the oxygen delivered

### Define what makes you Cyanotic

5 grams% reduced Hb in 100 ml of blood

### Define OxyHb

Combined or Oxygenated Hb
Hb bound with O2

### CarboxyHb

Carbon Monoxide bound to Hb

Example: