What is aneuploidy?
abnormal chromosome #
What is translocation?
What causes human syndromes?
chromosomal defects or pleiotropy
What is genetic heterogeneity?
several different genetic mutations that all lead to the same phenotypic effect
What is phenotypic heterogeneity?
several different phenotypic malformations that are all caused by the same genetic defect
What are teratogens?
exogenous agents that may cause birth defects
What is a cell-to-cell communication defect?
defects in one cell that may cause cancer in an adjacent cell
Paracrine pathway defects cause...
abnormal upregulation of division
Cancer cells behave like adult....
What are the three ways that cancer cells behave like adult stem cells?
migration, rapid division, redifferentiation
What are the three ways that knowledge of development may be used to treat disease?
paracrine factor blockage/upregulation, stem cell regeneration, induction of pleuripotency