B: Heme/Onc - anatomy
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8 terms
Terms | Definitions |
|---|---|
 Erythrocyte | myeloid lineage anucleate, biconcave large SA/volume ratio for easy gas exchange 90% glycolysis, 10% HMP shunt chloride-bicarb antiporter in cell membrane life span: 120 days |
| Platelet | myeloid lineage: megakaryocyte small, cytoplasmic fragment forms aggregates during primary hemostasis dense granules: ADP, Ca alpha granules: vWF, fibrinogen 33% stored in spleen life span: 8-10 days |
| Neutrophil | granulocyte, myeloid lineage comprises 40-75% of WBCs multilobed nucleus large, spherical azurophilic granules with hydrolytic enzymes, lysozyme, myeloperoxidase, & lactoferrin |
| Monocyte | mononuclear cell, myeloid lineage 2-10% of WBCs large, kidney-shaped nucleus extensive frosted-glass cytopalsm |
| Macrophage | mononuclear cell, myeloid lineage derived from monocytes in tissues phagocytosis activated by interferon-gamma from TH1 cells can function as APC with MHC Class II long life in tissues |
| Eosinophil | granulocyte, myeloid lineage 1-6% of all WBCs bilobate nucleus large red granules defense against helminths, phagocytosis of antigen-antibody complexes produces histaminase & arylsulfatase |
| Basophil | granulocytes, myeloid lineage <1% of WBCs bilobate nucleus dense blue granules with heparin, histamine, & leukotrienes mediates allergic reactions found in blood |
| Mast cell | blue granules with histamine, heparin, & eosinophilic chemotactic factors mediates allergic reaction found in tissue |
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