Final exam

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(endocrine) anterior pituitary (adenohypophysis)

is connected to the hypothalamus by blood vessels that form a portal system called the hypophyseal portal system.

Flatpeg

hormones secreted by the anterior pituitary are called

FSH (Follicle-stimulating hormone)

stimulates follicle development in the ovaries.

LH (Luteinizing hormone)

triggers ovulation.

ACTH( Adrenocorticotropic hormone)

released in response to stress

TSH ( Thyroid-stimulating hormone)

growth activity,

Prolactin

produces milk

GH (Growth hormone)

growth of skeletal muscles and long

The posterior pituitary (neurohypophysis)

is connected to the hypothalamus - it releases, but does not synthesize any hormones

Oxytocin (Posterior pituitary)

targets smooth muscle in the uterus and breasts.In the uterus, oxytocin stimulates uterine contractions, and in response to the sucking from an infant, oxytocin stimulates "milk letdown" in the breasts

ADH (Posterior pituitary)

targets the collecting ducts in the kidney and sweat glands in the skin to minimize water loss. It also directly causes arterioles to constrict thereby increasing blood pressure

Prolactin

Which of the following anterior pituitary hormones stimulates milk production?

Lutenizing hormone

Which of the following anterior pituitary hormones stimulates the gonads to secrete progesteroneand or testosterone?

Anterior pituitary produces

hGH, Human growth hormone

Oxytocin and antidiuretic hormone

Which of the following pairs of homrones are secreted by the posterior pituitary gland?

Thyroid hormone

Which of the following hormones promotes increases in the basal metobolic rate BMR?

Bones and skeletal

The major target of growth hormones are

True

ADH causes arterioles to constrict thereby increasing blood pressure.

Oxytocin

release is an example of positive feedback mechanism

Antidiuretic hormone ADH

is inhibited by alcohol

Arteries-

carry blood away from the heart.

Arterioles-

are small arteries that regulate blood flow into the capillaries.

Capillaries-

allow gas exchange between the blood and the body

Venules-

groups of capillaries that form small veins.

Veins-

blood vessels that carry blood from the tissues back to the heart.

Functions of Blood

Transportation- blood transports oxygen from the lungs to the cells of the body, and takes carbon dioxide from the cells to the lungs to be exhaled out (Gas transportation).
Regulation- maintains homeostasis by regulating blood pH, adjusting body temperature.
Protection- WBC's destroy pathogens, blood can stop excessive bleeding by clotting.

Erythrocytes(RBCs)-

the most abundant in the body; transports oxygen.
strange shape Biconcave, do not have a nucleus; which leaves space for oxygen transport.
- can change shape without breaking allowing them to squeeze single file through capillaries.
- contain hemoglobin which allows them to carry oxygen.
Hemoglobin has a protein called globin which house the pigment heme.
Heme has iron in its center that binds with 1 oxygen molecule.
life span of 120 days.

Thrombocytes( Platelets)-

responsible for blood clotting

Leukocytes( WBCs)-

the body's defense mechanism, immunity.They circulate in our body looking for infections so that they can take action.
WBC's have a nuclei and a full complement of other organelles.
Their life span can range from several months or years, but most live only a few days.WBC's can be broken down into two groups :Granulocytes and Agranulocytes
Granulocytes- have a grainy feature.
Agranulocytes- have a smooth appearance.

Platelets( Thrombocytes)-

are fragments of the cytoplasm; they lack a nucleus and are found circulating in the blood.
Platelets play a role in hemostasis.

Type or WBC granulocyte Basophills-

activated in allergic reactions.

Type or WBC granulocyte Esonophills-

activated in parasitic infections and allergies.

Type or WBC granulocyte Neutrophils-

Kill bacteria and foreign particles

Type of WBC agranulocyte Lymphocytes-

function with the immune system. (NK cells)

Type of WBC agranulocyte Monocytes-

function like neutrophils. They break down huge pieces of bacteria so it can kill it.

NLMEB

Neutrophiles, Lymphocytes, Monocytes, Erythrocytes, Basophils (Order from highest to lowest of WBC)

EPO erythropoietin

Which of the following hormones stimulates proliferation of red blood cells in red bone marrow?

Nutrient transport

The Major function of reb blood cells

Normal blood ph

7.35-7.45

Basophil

Which of the following blood cells release granules that intensify the inflammatory response and promote hypersensitivity (allergic reactions)

Basophil

Which of the following cells is not an agranular leukocyte?

Thrombocytes

Which of the following formed elements in blood are removed by fixed macrophages in the spleen and liver after only 5 to 9 days in the circulation?

Arterioles

This type of blood bessel plays a key role in regulationg blood flow into capillaries

Cardiac output is dependent on both

heart rate and stroke volume

Distributing vessels

Capillaries are also referred to as

Cardiac output

The volume of blood that circulates through the systemic or pulmonary blood vessels per minute is called

Arterioles

Which of the following types of blood vessels have high pulsing blood pressure?

70 is

Normal resting stroke volume is about ? mL

68mL

If a patients cardiac output is 4760/ min her heart reate is 70 beat/min, her stroke volume is ?

5 liters

In an adult the blood volume is about

True

Granulocytes called neutrophils are phagocytic and the most numerous of all white blood cells

False

In an ECG, the electrical activity assocated with atrial repolariztion is seen in the T wave

Right Ventricle

A 20 year old man is stabbed in the middle on the sternum at the level of the 5th rib. Which of the following was most likely penetrated?

Arterioles

The blood vessels that play the most importatnt role in the regulation of blood flow to a tissue and blood pressure are the

Veins

The total blood volume is distributed throughout the vasculature and heart, In which vessels is most of the blood?

Cardiac output times TPR

Mean Arterial pressure MAP is defined as ?

4900 mL

You can calculate your normal patients CO at a normal resting rate and you calculate?

Left ventricle

wall is the thickest because LV pushes blood to supply systemic circulation. pumps oxygenated blood onto aorta.

Right ventricle

wall is thinner because it supplies blood to the lungs( smaller flow resistance),pumps blood to pulmonary trunk.

P-wave-

atrial depolarization.

P-Q interval-

the time it takes the atrial kick to fill the ventricles.

QRS wave-

ventricular depolarization and atrial repolarization.

ST segment-

the time it takes to empty the ventricle before they repolarize.

Twave-

ventricular repolarization.

"lub-dub"

When you hear ? it is because you are hearing your valves open and close

The "Lub" (s1)

sound is heard when the mitral valve and tricupsid valve shut.

The "Dub" (S2)

sound is heard when the aortic valve and the semilunar valves shut.

The 5 Cardinal signs of inflammation:

Pain
Redness
Swelling
Heat
Loss of function

The inflammatory response

prevents the spread of harmful agents, disposes of pathogens, and dead tissues and promotes healing.

Steps to the inflammation process

Cells are injured
Histamine and kinis are released and they cause the blood vessels to dilate and the capillaries to become leaky.
Pain
Phagocytes and WBCs come to the scene of the injury via chemotaxis.

IgG antibody-

a monomer with two antigen-binding sites
Comprises 80% of total antibody
Only class able to cross the placenta
Provides long-term immunity

IgM -

a pentamer with ten antigen-binding sites
It is a great activator of complement, but has a short-lived response.
It is the first antibody to appear in an immune response

IgA -

a dimer with four antigen-binding sites
prevalent in body secretions like sweat, tears, saliva, breast milk and gastrointestinal fluids

IgD -

a monomer with a wide array of functions, some of which have been a puzzle since its discovery in 1964

Lipids

What cause lymph from the small intestines to appear white?

Macrophages

Which of these does not provide a physical and chemical barrier?

Mucus production

Which of the following is not a sign of inflammation ?

Antigen

Which induces the production of a specific antibody?

Antigen presenting cells

Which class of cells includes macrophages, B cells and dendritic cells ?

Helper T Cells

Which cells display CD4 proteins and interact with MHC Class II antigens

IgA

Which class of anitbodies is mainly found in sweat, tears, breast milk and GI secretions

IgM

Which class of antibodies indicates a recent invasion?

Mucous Cells

Which is part of the bodies second line of defense?

IgM

Which immunoglobulin is a pentamer?

IgG

A 2 month old baby girl is diagnosed with syphilis. Which of the following antibodies in the infants serum will determine that the syphilis is a results of sexual abuse?

True

Histamine and kinis are released and cause blood vessels to constrict and the capillaries to become leaky

IgE

A 7 year old female picks up a bag of peanuts and immediatley has an allergic reaction. What /immunoglobulin was involved in this episode

Stimulate the release of lysosomes

The inflammatory process begins with the release of chemicals which do all of the following except?

Stroke volume

stroke volume (SV) is the volume of blood pumped from one ventricle of the heart with each beat. SV is calculated using measurements of ventricle volumes from an echocardiogram and subtracting the volume of the blood in the ventricle at the end of a beat (called end-systolic volume) from the volume of blood just prior to the beat (called end-diastolic volume).

Sterling's Law

states that the stroke volume of the heart increases in response to an increase in the volume of blood filling the heart (the end diastolic volume).

cardiac output

increases or decreases in response to changes in heart rate or stroke volume.

When a person stands up:

cardiac output falls because of a fall in central venous pressure, which leads to a decrease in stroke volume.

The tongue is composed of skeletal muscle

it forces the moistened food bolus into position for swallowing and places the bolus into contact with the teeth for chewing.

Teeth

There are 20 deciduous or "baby teeth" which begin to erupt around 6 months of age.
There are 32 permanent teeth

Saliva

Saliva starts the process of chemical digestion of food.
Saliva is 99.5% water, with tiny amounts of dissolved ions, IgA, lysozyme (a bacteriolytic enzyme), and salivary amylase (a digestive enzyme that acts on starch).q

The stomachone

of the functions of the stomach is to serve as a mixing chamber and holding reservoir.

Pancrease

It secretes enzymes, which digest food in the small intestine, and sodium bicarbonate, which buffers the acidic pH of chyme.

Liver

Hepatocytes are the major functional cells of the liver.
the synthesis, transformation, and storage of proteins, carbohydrates, and fats detoxification, modification, and excretion of a variety of exogenous and endogenous substances

Gallbladder

the gallbladder contracts and ejects stored bile.After surgical removal of the
gall bladder (called a cholecystectomy), a person would experience severe indigestion if they ate a large meal high in fat content

Salivary Glands

Which of the following accessory organs produces a fluid to soften food?

Macrophages

Which of these does not provide a physical or chemical barrier?

Antigen

Which induces the production of a specific antibody?

Antigen presenting cells

Which class of cells includes macrophages, B cells and dendritic cells?

MHC antigen

To become activated which requires being bound to a foreign antigen and simultaneous costimulation

Helper T cells mature

in Bone

Natural killer cells

Which if part of the bodies second line of defense

Transfer of IgG from mother to fetus

Natural immunity is associated with which of the following ?

True

helper T lymphocytes cells are also called CD4

True

Helper T cells are involved in humoral immunity and cell mediated immunity

False

MHC I molecules are only found on APCs

Dilate blood vessels, Attract phagocytes to the area, Cause capillaries to become leaky, activate pain receptors

The inflammatory process begins with the release of chemicals which do all of the following

Cellular respiration

Glucose is the body's preferred source for making ATP.
The oxidation(OIL) of glucose to form ATP...
Glucose (C6H12O6) + O2 CO2 + H2O + ATP
... is known as "Cellular Respiration" and occurs in 4 steps

4 steps of cellular respiration

Glycolysis is occurring in the
cytoplasm
The Krebs cycle takes place in
the mitochondrial matrix
The cytochrome proteins of the
electron transport chain are embedded into the inner
the inner mitochondrial membrane

Regulation blood ionic composition, blood cell size, blood volume, blood pressure, blood pH

Function of the kidney

Interlobar arteries, arcuate arteries, glomerular capillaries, arcuate veins

Path of blood flow through the kidneys RSIAI AGEP IAISR

Which is the correct order of filtrate flow?

Glomerular capsule, proximal convulted tubes, loop of henle, distal convluted tubule, collecting duct

Proximal convoluted tubule

which structure of the nephron reabsords the most substances?

Glomerular capsule

This is the structure of the nephron that filters blood

Reabsorption

This term means the return of substances into the blood stream from the filtrate

Increase, sodium

Increased secretion of aldosterone would results in a _________ of blood_____________.

Urinalysis

An analysis of the physical, chemical, and microscopic properties of urine is called

95%

Water accounts for which percentage of teh toltal volume of urine?

Plasma creatine

This is a test to measure kidney function

Ureter

This transports urine from the kidney to the bladder

Glucosuria

Stress, causing excessive amounts of epinephrine secretion which stimulates glycogen breakdown, indicates which condition? This condition can also indicate diabetes mellitus

Decreased blood pressure

Absence of angiotensin converting enzyme will lead to

The afferent arterioles has a larger diameter

Glomerular pressure is due to a cariation in the size of the afferent and efferent arterioles. How the afferent arteriole differ in size form the efferent

Both voluntary and involuntary

Micturation is under what type of control

Proximal tubule

Most reabsorption of substances from the flomerular filtrate occurs in the ?

Liver

Angiotensinogen is produced by the

Nephron

This is the functional unit of the kidney

Increased urine volume, decreased urine osmolarity

Drinking large amount of beer results in

Proximal tubule

A 63 yr old hospitalized woman becomes oliguirc and confused her blood glucose if found to be only 35 mg. an intravenous access is obtained and an ampute of 50% dextrose is give followed by a continous infusion of 10% detrose. Most of the glucose that is filtered through the glomerulus undergoes reabsorption in which of the following ?

ADH

The permeability of the distal tubule and the cellecting duct is controlled by

Can be stimulated or innibited by higher centers in the brain, is stimulated by increased pressure in the bladder, can be stimulated by irritation of the bladder or urethra

The micturiation reflex

Retroperitoneal

The location of the kidneys in relationship to the peritoneal lining of the abdominal cavity is referred to as

Prostate

All of the following belong to the urinary sytem except the

Adrenal cortex

Which endocrine gland is primarily concerned with sodium and potassium ion balance in the body

Renal cortex

What is the outermost portion of the kidney

2

How many sphincters are found in the urethra

Ureter, urethra

The tube that carries urine from the urinary fladder to the outside world is the _____and the tuve that carries urine from the kidney to the urinary bladder is the ________

Angiotensin

What causes vessel constriction to reaise bloode pressure

Renin,lowered

The JGA produces _____which is needed which blood pressure is __________.

Renin-Angiotensin-Aldosterone System

When MAP falls the sympathetic nervous system signals the kidneys to be stimulated.
The afferent arterioles are stretched less and the juxtaglomerular cells release the enzyme renin.
Once renin is released from the kidney it acts on angiotensinogen which is produced by the liver.
Renin converts angiotensinogen to angiotensin I.

Angiotensin

causes blood vessels to constrict, and drives blood pressure up.

In order to activate this mechanism,

Angiotensin I must pick up angiotensin-converting enzyme( ACE) to convert it to fully functional Angiotensin II.

Angiotensin II functions:

Vasoconstriction decreases GFR.
It increases blood volume by increasing reabsorption of water and electrolytes in the PCT.
It stimulates the adrenal cortex to release aldosteron

Normal range of urine pH

4.6-8.0

How is metobolic alkalosis corrected

Respiratory compensation (hypoventilation)

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