Lecture 7: Long Term Potentiation

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Neurophysiology and Behavior

synaptogensis

the neural basis of learning and memoryhave been linked with the processes of long-term potentiations and________________.

Long Term Potentiation

refers to sustained changes in the efficiency of synaptic communication that results from activation of a synapse

Experience

__________ activates particular synapses throughout the brain.

activation increases

this synaptic ___________ ___________ the ease with which involved synapses communicate

synaptic efficiencies

changed __________ ____________ explain the learned responses and memories the result from experience.

stimulating pre synaptic

Research on Long Term Potentiation often involved ________ a ___ _________ neuron while recording from a post synaptic neuron.

recording post synaptic

Research on Long Term Potentiation often involved stimulating a presynaptic neuron while _________ from a ____ ____________ neuron

base line firing rates

Pre-synaptic test stimulations are conducted to measure _______ ________ post synaptic ______ _________.

more intensely

After measuring the baseline post-synaptic firing rate, the pre-synaptic neuron is ______ ________ stimulated for a period of time to simulate a "learning experience"

greater post synaptic

After the pre-synaptic neuron is more intensely stimulated for a period of time to simulate a learning experience, test stimulations are conducted at the base line level to reveal __________ _______ __________ activation than before the intense simulation (LTP)

hippocampal glutimate

To consider the neural basis of LTP, we'll focus on ________ neurons that communicate with __________.

Glutimate

_________ binds with two types of post-synaptic receptors: AMPA and NMDA

AMPA

________ receptors normally bind with glutimate and open NA+ channels the DEPOLARIZE the cell.

NMDA

________ receptors are normally blocked with Mg+ ions that prevent binding with glutimate.

removal NMDA

Strong activation of the post-synaptic neuron results in _________ of the Mg+ ions and frees the _________ receptors to bind with the glutimate.

Calcium second messengers

Binding of the NMDA receptors with glutimate causes ______ channels to open, which in turn activates __________ __________. (metabotropic)

Metabotropic second messengers

________ _________ _________ that result from NMDA receptor activation causes synaptic changes that are the basis of LTP

AMPA

the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: increased sentivity to _______ receptors

AMPA

the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: formation of new _______ receptors

retrograde messengers

the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: __________ ________ being sent to the presynaptic neuron that can cause increased glutimate release

increased glutimate

the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: retrograde messengers being sent to the presynaptic neuron that can cause __________ __________ release

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