| Term | Definition |
|---|
| Acute Leukemia | 20% Blasts in BM |
| ALL | Childrens Brain (CNS) |
| AML | 60 median |
| Acute | Ill at dx |
| Abnormal Hematopoiesis | decreased all lines |
| Almost always | Anemia |
| normal WBC | low |
| AML | Gingiva |
| Different Lines | Different Chemo Succept |
| ALL | lymphocytic/lymphoblastic |
| AML | myelocitic/blastic/ANLL |
| BLASTS | Large Nucleus/Loose Chromatin |
| BLAsts | No granules |
| Auer Rods | Only Myeloblasts |
| Auer Rods | Never Lymphoblasts |
| Sudan | granule membrane/ myelo/mono |
| MyeloPerox | granule content myelo/mono |
| Specific-esterase | myelo |
| Non-specific esterase | monocytes |
| PAS | gas-BLAST-chunky lymphoblasts |
| TdT | TandB nucleas enzymes |
| Myeloid | 11c/13/33/34 |
| Pre-B | 19,20,10,34 |
| B | 19,20,10,34 |
| T | 2,5,7 |
| AML | recurrent genetic abnormality/multi lineage/myelodysplastic bc TX |
| ALL | peak at 4yo |
| ALL | Leukemia or Tissue Lymphoma or Both |
| AML | t(8:21) inv(16) t(16;16) t(15;17) 11q23 deletions t(9;11) |
| t(8;21) | young AML - AML1 fuses ETO |
| t(8;21) chemo | good responce |
| inv(16) or t(16;16) | young AML leukemic BLASTS |
| t(8;21) | AML+ETO=many AUER RODS |
| t(8;21) | myeloid maturation: promyelo,myelo,metamyelo |
| t(16;16) or inv(16) | many EOSINOPHILS in BM |
| t(16;16) or inv(16) | core binding facto rearangement CBF-beta to MYHII (sm heavy chain) |
| inv16 prognosis | better |
| Acute Promyelocytic Leukemia | A type of AML with rearangement |
| AML (APL) | t(15;17) |
| APL | middle age |
| APL | Kidney Bean shape Nucleus: malignant promyelocyte |
| APL | many Auer Rods |
| APL | can be hyper or hypo granular promyelocyte neoplasm |
| Microgranular APL | "dusty" cytoplasm |
| APL | translocation RARalpha 17 --> PML (promyelocytic regulator)15 |
| APL | hyper granular form: high DIC risk |
| APL | Tx: all trans retinoic acid |
| 11q23 AML | monocytic diff. MLL rearangement (developmental regulator) |
| 11q23AML | MLL rearanged on 11: t(9:11) t(11;19) |
| AML:multilineage | Elderly |
| AML:multilineage | more than 50% bm dysplastic cells / 2+ LINEAGES |
| AML:multilineage | -5 / -7 / +8 / +11 |
| AML:multilineage; prognosis | Poor Prognosis |
| AML:MDS Tx related | alkylation/radiation or Topoisomerase II inhibitor |
| Topoisomerase II inhibitor | 1-12years - monocytic ; t(9;11) Like Acute Leukemia |
| AML:MDS Tx related | All 3 lines impacted |
| AML 11q23 | monocytic differation +- neutrophilic |
| AML:MDS Tx related | 5years; -5/-7 little to no responce to chemo |
| (AML noc) minimally differentiated | 20+% Blasts-no Aer rods/ + myeloid/ 5-70%chromosomal aber |
| (AML noc) without maturation | > |
| (AML noc) with maturation | 45% of AMLs - (youngsters) 20%Blasts <10% myeloid maturation YES AUER RODS |
| AMML (myelomonocytic) (AML noc) | 20<monocytic<80; no specifc aberation |
| Acute Monoblastic (AML noc) | >80% monocytic blasts |
| Acute Erythroid Leukemia (AML noc) | erythroblasts-rare-bad prognosis |
| Acute MegaKarioblastic (AML noc) | BF fibrosis is frequent: MegaK blasts and abnormal cytes |
| Acute Monocytic Leukemia | Promonocytes/monocytes ---gingiva blaster |
Combine with other sets
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